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Kaku Y#, Kuwata T#*, Zahid HM, Hashiguchi T, Noda T, Kuramoto N, Biswas S, Matsumoto K, Shimizu M, Kawanami Y, Shimura ...
miki
Publication Publication
Nomura Y, Matsuoka S, Okazaki M, Kuwata T, Matano T, Ishii H. 2021. Neutralizing Antibody Induction Associated with a G...
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Judicate GP, Barabona G, Kamori D, Mahiti M, Tan TS, Ozono S, Mgunya AS, Kuwata T, Matsushita S, Sunguya B, Lyamuya E, ...
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Katsuya H, Cook LBM, Rowan AG, Melamed A, Turpin J, Ito J, Islam S, Miyazato P, Jek Yang Tan B, Matsuo M, Miyakawa T, N...
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Yamamoto H, Sugawara Y, Sambommatsu Y, Shimata K, Yoshii D, Isono K, Honda M, Yamashita T, Matsushita S, Inomata Y, Hib...
News 新型コロナウイルスの変異株に有効な中和抗体についてCell Reportsで発表しました
新型コロナに感染して回復した症例から中和抗体を分離し、ウイルスへの強い結合活性をもった中和抗体が変異株へも有効であることを発表しました。
Resistance of SARS-CoV-2 variants to neutraliza...
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Matsuoka S#, Kuwata T#*, Ishii H#, Sekizuka T, Kuroda M, Sano M, Okazaki M, Yamamoto Y, Shimizu M, Matsushita S, Seki Y...
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Kobayakawa T, Tsuji K, Konno K, Himeno A, Masuda A, Yang T, Takahashi K, Ishida Y, Ohashi N, Kuwata T, Matsumoto K, Yos...
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Kaku, Y., Kuwata, T.*, Gorny M.K., Matsushita, S. Prediction of contact residues in anti-HIV neutralizing antibody by d...
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Maeda Y, Takemura T, Chikata, Kuwata T, Terasawa H, Fujimoto R, Kuse N, Akahoshi T, Murakoshi H, Tran G, Zhang Y, Pham ...
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Pisil, Y., Yazici, Z., Shida, H., Matsushita, S, Miura T. Specific Substitutions in Region V2 of gp120 env confer SHIV ...
Domestic Conference test dome
News 新センター発足
2019年４月１日より分野名が「ヒトレトロウイルス学共同研究センター・臨床レトロウイル学分野」になりました。
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Alam, M., Kuwata, T., Tanaka, K., Munatsir, A., Takahama, S., Shimura, K., Matsuoka, M., Fukuda, N., Morioka, H., Tamam...
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Thida, W., Kuwata, T., Maeda, Y., Yamashiro, T., Tran, G.V., Nguyen, K.V., Takiguchi, M., Gatanaga, H., Tanaka, K., Mat...
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Siddiqui, R,, Suzu, S., Ueno, M., Nasser, H., Koba, R., Bhuyan, F., Noyori, O., Yasuda-Inoue, M., Hishiki, T., Sukegawa...
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Kobayakawa, T., Ohashi, N., Hirota, Y., Takahashi, K., Yamada, Y., Narumi, T., Yoshimura, K., Matsushita, S., Harada S,...
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Komatsu, A., Ikeda, A., Kikuchi, A., Minami, C., Tan, M., Matsushita, S. Osteoporosis-Related Fractures in HIV-Infected...
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Stanoeva, K.R., König, A., Fukuda, A., Kawanami, Y., Kuwata, T., Satou, Y., Matsushita, S. Total HIV-1 DNA dynamics and...
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Miyazaki, N., Sugiura, W., Gatanaga, H., Watanabe, D., Yamamoto, Y., Yokomaku, Y., Yoshimura, K., Matsushita, S.; Japan...
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Tanaka, K., Kuwata, T., Alam, M., Kaplan., G, Takahama, S., Valdez, K.P.R., Roitburd-Berman, A., Gershoni. J.M., Matsus...
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Ohashi N., Harada S., Mizuguchi T., Irahara Y., Yamada Y., Kotani M., Nomura W., Matsushita S., Yoshimura K., Tamamura H...
Publication Maruta Y., Kuwata T., Tanaka K., Alam M., Ramirez-Valdez K-P., Egami Y., Yoshiaki Suwa Y., Morioka H., Matsushita S. Cross-neutralization activity of single-chain variable fragment (scFv) derived from anti-V3 monoclonal antibodies mediated by post-attachment binding. Jpn. J. Infect. Dis.,69(5):395-404, 2016
Maruta Y., Kuwata T., Tanaka K., Alam M., Ramirez-Valdez K-P., Egami Y., Yoshiaki Suwa Y., Morioka H., Matsushita S. Cro...
Publication Mizuguchi T., Harada S., Miura T., Ohashi N., Narumi T, Mori H.; Irahara Y; Yamada Y.; Nomura W., Matsushita S., Yoshimura K, Tamamura H. Minimally cytotoxic CD4 mimic as an HIV entry inhibitor. Bioorg Med Chem Lett. 26:397-400, 2016.
Mizuguchi T., Harada S., Miura T., Ohashi N., Narumi T, Mori H.; Irahara Y; Yamada Y.; Nomura W., Matsushita S., Yoshimu...
Publication Kuwata, T., Enomoto, I., Baba, M. and Matsushita S. Incompatible natures of HIV-1 envelope in resistance to the CCR5 antagonist cenicriviroc and neutralizing antibodies．Antimicrobial Agents and Chemotherapy (AAC) Accepted manuscript posted online 2 November 2015, doi: 10.1128/AAC.02285-15
Kuwata, T., Enomoto, I., Baba, M. and Matsushita S. Incompatible natures of HIV-1 envelope in resistance to the CCR5 ant...
Domestic Conference Muntasir, A., Kuwata, T., Ramirez, K., Maruta, Y., Tanaka, K., Shimura, K., Oishi, S., Fujii, N., Matsuoka, M., Matsushita, S. Effect of gp41 mutations on the sensitivity to neutralizing antibodies against HIV. 第29回日本エイズ学会学術集会・総会. 2015年11月30日-12月1日,東京.
Muntasir, A., Kuwata, T., Ramirez, K., Maruta, Y., Tanaka, K., Shimura, K., Oishi, S., Fujii, N., Matsuoka, M., Matsushi...
Domestic Conference 平田 泉、桑田岳夫、丸田泰広、田中和樹、Muntasir, A.、松下修三 ファージ・ライブラリーを用いた抗 V3単クローン抗体のエピトープ解析. 第29回日本エイズ学会学術集会・総会. 2015年11月30日-12月1日,東京.
平田 泉、桑田岳夫、丸田泰広、田中和樹、Muntasir, A.、松下修三 ファージ・ライブラリーを用いた抗 V3単クローン抗体のエピトープ解析. 第29回日本エイズ学会学術集会・総会. 2015年11月30日-12月1日,東京.
Domestic Conference Kuwata, T., Shimizu, M., Matsushita, S. Impact of gp41 mutations on resistance to B404, a broad neutralizing antibody reactive against a conformational epitope of SIV gp120. 第63回日本ウイルス学会学術集会. 2015年11月22日-24日，福岡市.
Kuwata, T., Shimizu, M., Matsushita, S. Impact of gp41 mutations on resistance to B404, a broad neutralizing antibody...
Domestic Conference Tanaka, K. Kuwata T., Maruta, Y., Muntasir, A., Kawanami, Y.，Matsushita, S. Enhanced neutralization by small antibody fragments targeting CD4i (CD4-induced) epitope on HIV-1 envelope glycoprotein. 第63回日本ウイルス学会学術集会. 2015年11月22日-24日，福岡市.
Tanaka, K. Kuwata T., Maruta, Y., Muntasir, A., Kawanami, Y.，Matsushita, S. Enhanced neutralization by small antibody f...
Publication Ramirez, K., Kuwata, T., Maruta, Y., Tanaka, K., Alam, M., Yoshimura, K., Matsushita, S. Complementary and synergistic activities of anti-V3, CD4bs and CD4i antibodies derived from a single individual can cover a wide range of HIV-1 strains. Virology, 475, 187-203, 2015.doi:10.1016/j.virol.2014.11.011
Ramirez, K., Kuwata, T., Maruta, Y., Tanaka, K., Alam, M., Yoshimura, K., Matsushita, S. Complementary and synergistic a...
Publication Matsushita, S., Yoshimura, K., Ramirez, k., Pisupati, J., Murakami, T., the KD-1002 Study Group. Passive transfer of neutralizing mAb KD-247 reduces plasma viral load in patients chronically infected with HIV-1. AIDS, 29(4), 453-462, 2015. doi: 10.1097/QAD.0000000000000570
Matsushita, S., Yoshimura, K., Ramirez, k., Pisupati, J., Murakami, T., the KD-1002 Study Group. Passive transfer of neu...
International Conference Stanoeva, K., Fukuda, A., Kawanami, Y, Kuwata, T., Satou, Y., Matsushita, S.: Levels of integrated proviral HIV-1 DNA load in Japanese patients on long-term ART. 16th Kumamoto AIDS Seminar. October 7-9, 2015. Kumamoto.
Stanoeva, K., Fukuda, A., Kawanami, Y, Kuwata, T., Satou, Y., Matsushita, S.: Levels of integrated proviral HIV-1 DNA lo...
International Conference Maruta, Y., Kuwata, T., Tanaka, K., Ramirez, K., Alam, M., Egami, Y., Suwa, Y., Morioka, H., Matsushita, S.: Post-attachment neutralization by single-chain variable fragments targeting the V3 loop of HIV-1 envelope. 16th Kumamoto AIDS Seminar. October 7-9, 2015. Kumamoto.
Maruta, Y., Kuwata, T., Tanaka, K., Ramirez, K., Alam, M., Egami, Y., Suwa, Y., Morioka, H., Matsushita, S.: Post-attach...
International Conference Alam, M., Kuwata, T., Maruta, Y., Ramirez K., Tanaka, K., Shimura, K., Oishi, S., Fujii, N., Matsuoka, M., Matsushita, S.: HIV-1 gp41 mutations against fusion inhibitor C34 showed enhanced sensitivity to neutralizing antibodies. 16th Kumamoto AIDS Seminar. October 7-9, 2015. Kumamoto.
Alam, M., Kuwata, T., Maruta, Y., Ramirez K., Tanaka, K., Shimura, K., Oishi, S., Fujii, N., Matsuoka, M., Matsushita, S...
International Conference Tanaka, K., Kuwata, T., Maruta, Y., Ramirez K., Alam, M., Kawanami, Y., Matsushita S.: Enhanced neutralization of HIV-1 primary isolates by the small antibody fragments targeting CD4-induced (CD4i) epitope. 16th Kumamoto AIDS Seminar. October 7-9, 2015. Kumamoto.
Tanaka, K., Kuwata, T., Maruta, Y., Ramirez K., Alam, M., Kawanami, Y., Matsushita S.: Enhanced neutralization of HIV-1 ...
International Conference Alves, G., Kuwata T., Tanaka Y., Ariumi, Y., Maruta, Y., Tanaka, K., Alam, M., Stanoeva, K., Hirata, I., Matsushita, S.: Constitutive expression of anti-HIV-1 scFv intrabodies transduced by an HIV-1-based Lentivirus vector. 16th Kumamoto AIDS Seminar. October 7-9, 2015. Kumamoto.
Alves, G., Kuwata T., Tanaka Y., Ariumi, Y., Maruta, Y., Tanaka, K., Alam, M., Stanoeva, K., Hirata, I., Matsushita, S.:...
International Conference Hirata, I., Kuwata, T., Maruta, Y., Tanaka, K., Alam, M., Matsushita, S.: Epitope analysis of anti-V3 monoclonal antibodies using phage display library. 16th Kumamoto AIDS Seminar. October 7-9, 2015. Kumamoto.
Hirata, I., Kuwata, T., Maruta, Y., Tanaka, K., Alam, M., Matsushita, S.: Epitope analysis of anti-V3 monoclonal antibod...
International Conference Kuwata, T., Shimizu, M., Matsushita, S. Impact of gp41 mutations for escape from a broad neutralizing antibody against SIV. 16th Kumamoto AIDS Seminar. October 7-9, 2015. Kumamoto.
Kuwata, T., Shimizu, M., Matsushita, S. Impact of gp41 mutations for escape from a broad neutralizing antibody against S...
未分類 IAS 2015 Vancouver,Canada（2015/7/19-22）にて、博士課程3年の田中和樹さんが「IAS Towards an HIV Cure Scholarship Programme」を獲得しました。
IAS 2015 Vancouver,Canada（2015/7/19-22）にて、博士課程3年の田中和樹さんが「IAS Towards an HIV Cure Scholarship Programme」を獲得しました。
詳し...
International Conference Tanaka, K., Kuwata, T., Maruta, Y., Ramirez, K., Alam, M., Egami, Ikumi Y., Enomoto, I., Kawanami, Y., Matsushita. S. Potent and broad neutralizing activity of small antibody fragments targeting CD4i (CD4-induced) epitope. The 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015) the Vancouver 19-22 July 2015. Vancouver, Canada.
Tanaka, K., Kuwata, T., Maruta, Y., Ramirez, K., Alam, M., Egami, Ikumi Y., Enomoto, I., Kawanami, Y., Matsushita. S. Po...
Domestic Conference 桑田岳夫、田中和樹、丸田泰広、松下修三. Neutralization of HIV-1 by single chain antibody fragments (scFv) against gp120. 白馬シンポジウム in 米子. 2015年6 月19 日-20 日, 米子市.
桑田岳夫、田中和樹、丸田泰広、松下修三. Neutralization of HIV-1 by single chain antibody fragments (scFv) against gp120. 白馬シンポジウム in 米子. 20...
Domestic Conference 田中和樹、桑田岳夫、丸田泰広、松下修三. Potent and broad neutralizing activity of small antibody fragments targeting CD4i (CD4-induced) epitope. 白馬シンポジウム in 米子. 2015年6 月19 日-20 日(土).米子市.
田中和樹、桑田岳夫、丸田泰広、松下修三. Potent and broad neutralizing activity of small antibody fragments targeting CD4i (CD4-induced) ep...
Publication Boonchawalit, S., Harada, S, Shirai, N., Gatanaga, H., Oka, S., Matsushita, S., and Yoshimura, K. Impact of maraviroc-resistant mutation M434I in the C4 region of HIV-1 gp120 on sensitivity to antibody-mediated neutralization. Jpn. J. Infec.t Dis.,69, 236-243, 2015.
Boonchawalit, S., Harada, S, Shirai, N., Gatanaga, H., Oka, S., Matsushita, S., and Yoshimura, K. Impact of maraviroc-re...
International Conference Muntasir, A., Kuwata, T., Ramirez, K., Maruta, Y., Tanaka K., Shimura, K., Oishi, S., Fujii, N., Matsuoka, M., Matsushita, S. Enhanced Neutralization of HIV-1 with Fusion Inhibitor Resistant Mutations. The annual Conference on Retroviruses and Opportunistic Infections (CROI 2015). February 23-26, 2015. Seattle, Washington, USA
Muntasir, A., Kuwata, T., Ramirez, K., Maruta, Y., Tanaka K., Shimura, K., Oishi, S., Fujii, N., Matsuoka, M., Matsushit...
International Conference Matsushita, S., Ramirez, K.P., Maruta, Y., Tanaka, K., Muntasir, A., Kuwata, T., Pisupait, J., Murakami, T., Yoshimura, K. Therapeutic application of neutralizing antibodies based on the recent data on complementary and synergistic activities against a wide range of HIV-1 strains. the 17th International Conference on Emerging Infectious Diseases (EID) Emerging Infectious Diseases Meeting Jan. 26-27, 2015. Taipei, Taiwan
Matsushita, S., Ramirez, K.P., Maruta, Y., Tanaka, K., Muntasir, A., Kuwata, T., Pisupait, J., Murakami, T., Yoshimura, ...
Publication Kirby, K.A., Ong Y.T., Hachiya, A., Laughlin, T.G., Chiang, L.A., Pan, Y., Moran, J.L., Marchand, B., Singh, K., Gallazzi, F., Quinn, T.P., Yoshimura, K., Murakami, T., Matsushita, S., Sarafianos, S.G.. Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247. The FASEB Journal, 29(1), 70-80, 2015.
Kirby, K.A., Ong Y.T., Hachiya, A., Laughlin, T.G., Chiang, L.A., Pan, Y., Moran, J.L., Marchand, B., Singh, K., Gallazz...
International Conference Maruta, Y ., Kuwata, T., Tanaka, K ., Nakahara, Y ., Ramirez, K., Muntasir, A., Egami, Y., Hirata, I., Suwa, Y ., Morioka, H., Matsushita, S. Post-attachment Neutralization by Single-chain Variable Fragment (scFv) from an Anti-V3 Monoclonal Antibody with Cross-reactivity. Korea-Japan Joint Seminar on HIV/AIDS. January 10, 2015. Kumamoto.
Maruta, Y ., Kuwata, T., Tanaka, K ., Nakahara, Y ., Ramirez, K., Muntasir, A., Egami, Y., Hirata, I., Suwa, Y ., Moriok...
Domestic Conference Ramirez, K.P., Kuwata, T., Maruta, Y, Tanaka K., Muntasir, A., Yoshimura, K., Matsushita, S. Complementary effect of anti-V3, CD4bs and CD4i antibodies accounts for cross-neutralizing and non-neutralizing activities against HIV-1. 第28回日本エイズ学会学術集会・総会. 2014年12月3日-5日, 大阪.
Ramirez, K.P., Kuwata, T., Maruta, Y, Tanaka K., Muntasir, A., Yoshimura, K., Matsushita, S. Complementary effect of ant...
Domestic Conference 江上由華、丸田泰広、田中和樹、Muntasir A., Ramirez K., 桑田岳夫、松下修三. V3エピトープへの交叉反応性をもつ中和抗体の遺伝子組み換えによる小型化の試み. 第28回日本エイズ学会学術集会・総会. 2014年12月3日-5日, 大阪.
江上由華、丸田泰広、田中和樹、Muntasir A., Ramirez K., 桑田岳夫、松下修三. V3エピトープへの交叉反応性をもつ中和抗体の遺伝子組み換えによる小型化の試み. 第28回日本エイズ学会学術集会・総会. 2014年12...
Domestic Conference 桑田岳夫、松下修三. 強力な抗SIV中和抗体B404からの逃避メカニズムの解析. 第28回日本エイズ学会学術集会・総会. 2014年12月3日-5日, 大阪.
桑田岳夫、松下修三. 強力な抗SIV中和抗体B404からの逃避メカニズムの解析. 第28回日本エイズ学会学術集会・総会. 2014年12月3日-5日, 大阪.
International Conference Kuwata, T., Yoshimura, K., Wu, F., Ourmanov, I., Hirsch, V.M., Yokoyama, M., Sato H., and Matsushita, S. Mutations in gp41 is Critical to Escape from B404, a Broad Neutralizing Antibody Against SIV, Which Recognizes a V3/V4 Conformational Epitope. 32nd Annual Symposium on Nonhuman Primate Models for AIDS. November 11 – 14, 2014. Portland, Oregon, USA.
Kuwata, T., Yoshimura, K., Wu, F., Ourmanov, I., Hirsch, V.M., Yokoyama, M., Sato H., and Matsushita, S. Mutations in g...
International Conference Maruta, Y., Kuwata, T., Tanaka K., Nakahara,Y., Ramirez, K., Alam, M., Egami, Y., Hirata I., Suwa, Y., Morioka, H., Matsushita, S. Mechanism of post-attachment neutralization of single-chain variable fragment (scFv) from anti-V3 monoclonal antibody against HIV-1. HIV R4P 2014 . October 28-31,2014. Cape Town, South Africa.
Maruta, Y., Kuwata, T., Tanaka K., Nakahara,Y., Ramirez, K., Alam, M., Egami, Y., Hirata I., Suwa, Y., Morioka, H., Mats...
Publication Yoshimura, K., Harada, S., Boonchawalit, S., Kawanami, Y., and Matsushita, S. Impact of maraviroc-resistant and low-CCR5- adapted mutations induced by in vitro passage on sensitivity to anti-envelope neutralizing antibodies. Journal of General Virology, 95, 1816-1826, 2014.
Yoshimura, K., Harada, S., Boonchawalit, S., Kawanami, Y., and Matsushita, S. Impact of maraviroc-resistant and low-CCR5...
International Conference Matsushita, S., Ramirez, K.P., Maruta, Y., Tanaka, K., Muntasir, A., Kuwata, T., Pisupait, J., Murakami, T., Yoshimura, K. Therapeutic application of neutralizing antibodies based on the recent data on complementary and synergistic activities against a wide range of HIV-1 strains. 15th Kumamoto AIDS Seminar. October 1-3, 2014. Kumamoto.
Matsushita, S., Ramirez, K.P., Maruta, Y., Tanaka, K., Muntasir, A., Kuwata, T., Pisupait, J., Murakami, T., Yoshimura, ...
International Conference Kuwata, T., Enomoto, I., Baba, M., Matsushita, S. Acquisition of resistance to the CCR5 antagonist cenicriviroc renders HIV-1 sensitive to neutralizing antibodies. 15th Kumamoto AIDS Seminar. October 1-3, 2014. Kumamoto.
Kuwata, T., Enomoto, I., Baba, M., Matsushita, S. Acquisition of resistance to the CCR5 antagonist cenicriviroc renders ...
International Conference Ramirez, K.P., Kuwata, T., Maruta, Y, Tanaka K., Muntasir, A., Yoshimura, K., Matsushita, S. Evaluation of complementarity and synergy of conventional anti-HIV-1 antibodies derived from a single individual, 15th Kumamoto AIDS Seminar. October 1-3, 2014. Kumamoto.
Ramirez, K.P., Kuwata, T., Maruta, Y, Tanaka K., Muntasir, A., Yoshimura, K., Matsushita, S. Evaluation of complementari...
International Conference Muntasir, A., Kuwata, T., Ramirez, K., Enomoto, I., Maruta, Y., Tanaka K., Rahman K., Nakahara,Y., Egami, Y., Kawanami, Y., Murayama, H., Shimura, K., Matsuoka, M., Matsushita, S. Mutations in gp41 that confer resistance to fusion inhibitors enhance the neutralization sensitivity to antibodies against both gp41 and gp120. 15th Kumamoto AIDS Seminar. October 1-3, 2014. Kumamoto.
Muntasir, A., Kuwata, T., Ramirez, K., Enomoto, I., Maruta, Y., Tanaka K., Rahman K., Nakahara,Y., Egami, Y., Kawanami, ...
International Conference Maruta, Y., Kuwata, T., Tanaka K., Nakahara,Y., Ramirez, K., Alam, M., Egami, Y., Hirata I., Suwa, Y., Morioka, H., Matsushita, S. Mechanism of post-attachment neutralization of single-chain variable fragment (scFv) from anti-V3 monoclonal antibody against HIV-1. 15th Kumamoto AIDS Seminar. October 1-3, 2014. Kumamoto.
Maruta, Y., Kuwata, T., Tanaka K., Nakahara,Y., Ramirez, K., Alam, M., Egami, Y., Hirata I., Suwa, Y., Morioka, H., Mats...
International Conference Tanaka K., Kuwata, T., Maruta, Y., Ramirez, K., Muntasir, A., Egami, Y., Enomoto, I., Kawanami, Y., Matsushita, S. Construction of neutralizing antibody fragment against V3 with a broad cross-reactivity. 15th Kumamoto AIDS Seminar. October 1-3, 2014. Kumamoto.
Tanaka K., Kuwata, T., Maruta, Y., Ramirez, K., Muntasir, A., Egami, Y., Enomoto, I., Kawanami, Y., Matsushita, S. Const...
International Conference Boonchawalit, S., Harasda, S., Matsushita, S., Yoshimura, K.: Impact of Maraviroc (MCV)-resistant mutations in C1 and C4 regions of gp120 on sensitivity to antibody-mediated neutralization. 20th International AIDS Conference. Melbourne, Australia. July 20-25,2014.
Boonchawalit, S., Harasda, S., Matsushita, S., Yoshimura, K.: Impact of Maraviroc (MCV)-resistant mutations in C1 and C4...
Domestic Conference 桑田岳夫：SIVサル・モデルを用いた中和抗体の解析. 第17回 日本レトロウイルス研究会 夏期セミナー.2014 7.3-5(7/3発表)静岡県熱海市.
桑田岳夫：SIVサル・モデルを用いた中和抗体の解析. 第17回 日本レトロウイルス研究会 夏期セミナー.2014 7.3-5(7/3発表)静岡県熱海市.
Domestic Conference 桑田岳夫、馬場昌範、松下修三：CCR5阻害薬Cenicrivirocへの耐性と中和抗体への抵抗性は両立しない. 白馬シンポジウムin熊本. 2014.6.13-14. 熊本市.
桑田岳夫、馬場昌範、松下修三：CCR5阻害薬Cenicrivirocへの耐性と中和抗体への抵抗性は両立しない. 白馬シンポジウムin熊本. 2014.6.13-14. 熊本市.
Domestic Conference 桑田岳夫、馬場昌範、松下修三：HIV-1 のCCR5 阻害薬への耐性と中和抗体への抵抗性は両立しない第２４回抗ウイルス療法研究会総会. 2014.5.7-9.(5/7発表) 山梨県富士吉田市.
桑田岳夫、馬場昌範、松下修三：HIV-1 のCCR5 阻害薬への耐性と中和抗体への抵抗性は両立しない第２４回抗ウイルス療法研究会総会. 2014.5.7-9.(5/7発表) 山梨県富士吉田市.
Domestic Conference 松下修三, 大類 諭, Post F, Winston J, Hendry B, Gazzard B, Molina J, Liu HC, Piontkowsky D, Cheng AK, Rhee MS, Szwarcberg J. EVG/COBI/FTC/TDF 第III 相臨床試験における腎機能に関連する安全性の評価（投与96 週時点）－アジア人についての層別集計結果を含む－. 第27回日本エイズ学会学術集会・総会. 2013年11月20日-22日, 熊本.
松下修三, 大類 諭, Post F, Winston J, Hendry B, Gazzard B, Molina J, Liu HC, Piontkowsky D, Cheng AK, Rhee MS, Szwarcberg J. EV...
Domestic Conference 桑田岳夫. シンポジウム６-中和抗体と抗CCR5 阻害薬(Env). 第27回日本エイズ学会学術集会・総会. 2013年11月20日-22日, 熊本.
桑田岳夫. シンポジウム６-中和抗体と抗CCR5 阻害薬(Env). 第27回日本エイズ学会学術集会・総会. 2013年11月20日-22日, 熊本.
Domestic Conference Ramirez K, Kuwata T, Maruta Y, Tanaka K, Alam M, Kawanami Y, Enomoto I, Tamamura H, Yoshimura K, Matsushita S. Combination of anti-V3 antibodies as a possible strategy for controllingtransmitted/founder virus. 第27回日本エイズ学会学術集会・総会. 2013年11月20日-22日, 熊本.
Ramirez K, Kuwata T, Maruta Y, Tanaka K, Alam M, Kawanami Y, Enomoto I, Tamamura H, Yoshimura K, Matsushita S. Combinati...
Domestic Conference 丸田泰広, 桑田岳夫, 田中和樹, Ramirez K, Alam M, 江上由華, 中原悠介, 諏訪喜昭, 森岡弘志, 松下修三. 抗V3 抗体の小型化によるCD4 結合後のHIV-1 中和活性の増進. 第27回日本エイズ学会学術集会・総会. 2013年11月20日-22日, 熊本.
丸田泰広, 桑田岳夫, 田中和樹, Ramirez K, Alam M, 江上由華, 中原悠介, 諏訪喜昭, 森岡弘志, 松下修三. 抗V3 抗体の小型化によるCD4 結合後のHIV-1 中和活性の増進. 第27回日本エイズ学会学術集会・総...
Domestic Conference Alam M, Kuwata T, Ramirez K, Enomoto I, Maruta Y, Tanaka K, Rahman K, Egami Y, Kawanami Y, Murayama H, Shimura K, Matsuoka M, Matsushita S. Enfuvirtide resistant mutation N43Dis associated with the enhancedneutralization by 10E8, a broadlyneutralizing antibody against gp41 MPER. 第27回日本エイズ学会学術集会・総会. 2013年11月20日-22日, 熊本.
Alam M, Kuwata T, Ramirez K, Enomoto I, Maruta Y, Tanaka K, Rahman K, Egami Y, Kawanami Y, Murayama H, Shimura K, Matsuo...
Domestic Conference 田中和樹, 桑田岳夫, 丸田泰広, Ramirez K, 松下修三. gp120のCD4-induced epitope に結合する中和抗体の小型化とその特性の検討. 第27回日本エイズ学会学術集会・総会. 2013年11月20日-22日, 熊本.
田中和樹, 桑田岳夫, 丸田泰広, Ramirez K, 松下修三. gp120のCD4-induced epitope に結合する中和抗体の小型化とその特性の検討. 第27回日本エイズ学会学術集会・総会. 2013年11月20日-22日,...
International Conference Alam M, Kuwata T, Ramirez K, Enomoto I, Maruta Y, Tanaka K, Rahman K, Egami Y, Kawanami Y, Murayama H, Shimura K, Matsuoka M, Matsushita S. Effects of Enfuvirtide resistant mutations on the sensitivity to neutralizing antibodies. 14th Kumamoto AIDS Seminar. 29-31 October 2013, Kumamoto.
Alam M, Kuwata T, Ramirez K, Enomoto I, Maruta Y, Tanaka K, Rahman K, Egami Y, Kawanami Y, Murayama H, Shimura K, Matsuo...
International Conference Maruta Y, Kuwata T, Tanaka K, Nakahara Y, Ramirez K, Alam M, Egami Y, Suwa Y, Morioka H, Matsushita S. Post-attachment neutralization as a mechanism of efficient activities of scFv from anti-V3 monoclonal antibody. 14th Kumamoto AIDS Seminar. 29-31 October 2013, Kumamoto.
Maruta Y, Kuwata T, Tanaka K, Nakahara Y, Ramirez K, Alam M, Egami Y, Suwa Y, Morioka H, Matsushita S. Post-attachment n...
International Conference Tanaka K, Kuwata T, Maruta Y, Ramirez K, Kawanami Y, Enomoto I, Matsushita S. Miniaturization of antibodies against CD4-induced epitope on gp120. 14th Kumamoto AIDS Seminar. 29-31 October 2013, Kumamoto.
Tanaka K, Kuwata T, Maruta Y, Ramirez K, Kawanami Y, Enomoto I, Matsushita S. Miniaturization of antibodies against CD4-...
International Conference Ramirez K, Kuwata T, Maruta Y, Tanaka K, Alam M, Rahman K, Egami Y, Kawanami Y, Enomoto I, Tamamura H, Yoshimura K, Matsushita S. Can antibodies contribute to controlling infection with transmitted/founder virus? 14th Kumamoto AIDS Seminar. 29-31 October 2013, Kumamoto.
Ramirez K, Kuwata T, Maruta Y, Tanaka K, Alam M, Rahman K, Egami Y, Kawanami Y, Enomoto I, Tamamura H, Yoshimura K, Mats...
International Conference Kuwata T, Takaki K, Yoshimura K, Enomoto I, Wu F, Ourmanov I, Hirsch VM, Yokoyama M, Sato H, Matsushita S. Identification of the Env region responsible for the resistance to B404, a potent neutralizing antibody against SIV. 14th Kumamoto AIDS Seminar. 29-31 October 2013, Kumamoto.
Kuwata T, Takaki K, Yoshimura K, Enomoto I, Wu F, Ourmanov I, Hirsch VM, Yokoyama M, Sato H, Matsushita S. Identificatio...
Publication Otsuki, H., Hishiki, T., Miura, T., Hashimoto, C., Narumi, T., Tamamura, H., Yoshimura, K., Matsushita, S., and Igarashi, T. Generation of a replication-competent simian-human immunodeficiency virus, the neutralization sensitivity of which can be enhanced in the presence of a small-molecule CD4 mimic. J. Gen. Virol. 94: 2710-2716, 2013.
Otsuki, H., Hishiki, T., Miura, T., Hashimoto, C., Narumi, T., Tamamura, H., Yoshimura, K., Matsushita, S., and Igarashi...
Publication Hashimoto, C., Narumi, T., Otsuki, H., Hirota, Y., Arai, H., Yoshimura, K., Harada, S., Ohashi, N., Nomura, W., Miura, T., Igarashi, T., Matsushita, S. and Tamamura, H. A CD4 mimic as an HIV entry inhibitor: Pharmacokinetics. Bioorg. Med. Chem. 21: 7884?7889 , 2013.
Hashimoto, C., Narumi, T., Otsuki, H., Hirota, Y., Arai, H., Yoshimura, K., Harada, S., Ohashi, N., Nomura, W., Miura, T...
International Conference Ramirez K, Kuwata T, Maruta Y, Tanaka K, Alam M, Rahman K, Kawanami Y, Enomoto I, Tamamura H, Yoshimura K, Matsushita S. Improving the brodality and potency of neutralizing anti-HIV-1 antibodies with a CD4 mimetic compound. AIDS Vaccine 2013. 7-10 October 2013. Barcelona, Spain.
Ramirez K, Kuwata T, Maruta Y, Tanaka K, Alam M, Rahman K, Kawanami Y, Enomoto I, Tamamura H, Yoshimura K, Matsushita S....
International Conference Kuwata T, Takaki K, Yoshimura K, Enomoto I, Wu F, Ourmanov I, Hirsch VM, Yokoyama M, Sato H, Matsushita S. Analysis of Env regions important for binding and resistance to B404, a potent neutralizing antibody against SIV. AIDS Vaccine 2013. 7-10 October 2013. Barcelona, Spain.
Kuwata T, Takaki K, Yoshimura K, Enomoto I, Wu F, Ourmanov I, Hirsch VM, Yokoyama M, Sato H, Matsushita S. Analysis of E...
Publication The Mind Exchange Working Group (Antinori A, Arendt G, Grant I, Matsushita S, et al.) Assessment, Diagnosis, and Treatment of HIV-Associated Neurocognitive Disorder: A Consensus Report of the Mind Exchange Program. Clin Infect Dis. 56(7):1004 -1017, 2013
The Mind Exchange Working Group (Antinori A, Arendt G, Grant I, Matsushita S, et al.) Assessment, Diagnosis, and Treatme...
Publication Harada S, Yoshimura K, Yamaguchi A, Yusa K, Matsushita S. Impact of antiretroviral pressure on selection of primary HIV-1 envelope sequences in vitro. J. Gen. Virol. 94:933-943, 2013.
Harada S, Yoshimura K, Yamaguchi A, Yusa K, Matsushita S. Impact of antiretroviral pressure on selection of primary HIV-...
Publication Kuwata T, Takaki K, Yoshimura K, Enomoto I, Wu F, Ourmanov KI, Hirsch VM, Yokoyama M, Sato H, Matsushita S. Conformational Epitope Consisting of the V3 and V4 Loops as a Target for Potent and Broad Neutralization of Simian Immunodeficiency Viruses. J. Virol. 87:5424-5346, 2013.
Kuwata T, Takaki K, Yoshimura K, Enomoto I, Wu F, Ourmanov KI, Hirsch VM, Yokoyama M, Sato H, Matsushita S. Conformation...
Publication Narumi T, Arai H, Yoshimura K, Harada S, Hirota Y, Ohashi N, Hashimoto C, Nomura W, Matsushita S, Tamamura H.: CD4 mimics as HIV entry inhibitors: lead optimization studies of the aromatic substituents. Bioorganic & Medicinal Chemistry. 21:2518-2526, 2013 .
Narumi T, Arai H, Yoshimura K, Harada S, Hirota Y, Ohashi N, Hashimoto C, Nomura W, Matsushita S, Tamamura H.: CD4 mimic...
Publication Kuwata T, Takaki K, Enomoto I, Kazuhisa Y, and Matsushita S. Increased infectivity in human cells and resistance to antibody-mediated neutralization by truncation of the SIV gp41 cytoplasmic tail. Frontiers in Microbiology/Virology. 4:1-7, 2013.
Kuwata T, Takaki K, Enomoto I, Kazuhisa Y, and Matsushita S. Increased infectivity in human cells and resistance to anti...
Publication Nishijima T, Takano M, Ishisaka M, Komatsu H, Gatanaga H, Kikuchi Y, Endo T, Horiba M, Kaneda S, Uchiumi H, Koibuchi T, Naito T, Yoshida M, Tachikawa N, Ueda M, Yokomaku Y, Fujii T, Higasa, S., Takada, K., Yamamoto, M, Matsushita S, Tateyama M, Tanabe Y, Mitsuya H, Oka S, on behalf of the Epzicom-Truvada study team: Abacavir/Lamivudine versus Tenofovir/Emtricitabine with Atazanavir/Ritonavir for Treatment-naive Japanese Patients with HIV-1 Infection: A Randomized Multicenter Trial. Internal Medicine. 52: 735-744, 2013.
Nishijima T, Takano M, Ishisaka M, Komatsu H, Gatanaga H, Kikuchi Y, Endo T, Horiba M, Kaneda S, Uchiumi H, Koibuchi T, ...
International Conference Matsushitas S., Yoshimura K., Maeda T., Murakami T., KD-1002 Principal Investigators and The Protocol Team of Quintiles. Passive transfer of neutralizing monoclonal antibody KD-247 reduces plasma viral load in patientschronically infected with HIV-1: a phase-1b clinical study of a humanized monoclonal antibody KD-247 (KD-1002).
Matsushita S., Yoshimura K., Maeda T., Murakami T., KD-1002 Principal Investigators and The Protocol Team of Quintiles. ...
International Conference Matsushita S., Yoshimura K., Maeda T., Murakami T., KD-1002 Principal Investigators and The Protocol Team of Quintiles. Passive transfer of neutralizing monoclonal antibody KD-247 reduces plasma viral load in patientschronically infected with HIV-1: a phase-1b clinical study of a humanized monoclonal antibody KD-247 (KD-1002).
Matsushita S., Yoshimura K., Maeda T., Murakami T., KD-1002 Principal Investigators and The Protocol Team of Quintiles. ...
International Conference Matsushita S. Passive transfer of neutralizing monoclonal antibody KD-247 reduces plasma viral load in patients chronically infected with HIV-1：A Phase-1b clinical study of a humanized monoclonal antibody KD-247 (KD-1002). IAS Towards an HIV Cure Symposium. 29th-30th June 2013 , Kuala Lumpur.
Matsushita S. Passive transfer of neutralizing monoclonal antibody KD-247 reduces plasma viral load in patients chronic...
Domestic Conference 田中和樹、桑田岳夫、丸田泰広、園田貴丈、 Kristel Ramirez、松下修三.gp120のCD4-induced epitopeに結合する中和抗体の解析. 第26回日本エイズ学会学術集会・総会. 2012.11.24-11.26.（11/24発表） 横浜.
田中和樹、桑田岳夫、丸田泰広、園田貴丈、 Kristel Ramirez、松下修三.gp120のCD4-induced epitopeに結合す る中和抗体の解析. 第26回日本エイズ学会学術集会・総会. 2012.11.24-11.26....
Domestic Conference 園田貴丈、Samatchaya Boonchawalit、田中和樹、丸田泰広、Kristel Ramirez、 桑田岳夫、松下修三:CRF01_AE HIV-1 感染症例IgGの交差中和活性の解析.第26回日本エイズ学会学術集会・総会. 2012.11.24-11.26.（11/24発表） 横浜.
園田貴丈、Samatchaya Boonchawalit、田中和樹、丸田泰広、Kristel Ramirez、 桑田岳夫、松下修三: CRF01_AE HIV-1 感染症例IgGの交差中和 活性の解析. 第26回日本エイズ学会学術集会・総会...
Domestic Conference 桑田岳夫、吉村和久、松下修三：SIV感染サルから分離された中和抗体B404はV3,V4ループを含むEnv立体構造を認識する 第26回日本エイズ学会学術集会・総会. 2012.11.24-11.26.（11/24発表）横浜.
桑田岳夫、吉村和久、松下修三：SIV感染サルから分離された中和抗体B404はV3,V4ループを含むEnv立体構造を認識する 第26回日本エイズ学会学術集会・総会. 2012.11.24-11.26. 横浜.
International Conference Sonoda T., Boonchawalit S., Gatanaga H., Tanaka K., Maruta Y., Ramirez K., Kuwata T., Matsushita S.:Cross subtype neutralizing activity of plasma antibodies from patients infected with HIV-1 CRF01_AE HIV-1. 13th Kumamoto AIDS Seminar GCOE Joint International Symposium, 2012.10.25-26, Aso, Kumamoto.
Sonoda T., Boonchawalit S., Gatanaga H., Tanaka K., Maruta Y., Ramirez K., Kuwata T., Matsushita S.:Cross subtype neutra...
International Conference Ramirez K, Kuwata T., Maruta Y., Tanaka K., Matsushita S.: Sonoda, T, Kawanami Y, Takaki K, Enomoto I. Efficient isolation of monoclonal antibodies against HIV-1from HIV-1 infected patients. 13th Kumamoto AIDS Seminar GCOE Joint International Symposium, 2012.10.25-26, Aso, Kumamoto.
Ramirez K, Kuwata T., Maruta Y., Tanaka K., Matsushita S.: Sonoda, T, Kawanami Y, Takaki K, Enomoto I. Efficient isolat...
International Conference Tanaka K., Kuwata T., Maruta Y., Ramirez K., Matsushita S.: Analysis of antibodies to CD4-induced epitope on gp120. 13th Kumamoto AIDS Seminar GCOE Joint International Symposium, 2012.10.25-26, Aso, Kumamoto.
Tanaka K., Kuwata T., Maruta Y., Ramirez K., Matsushita S.: Analysis of antibodies to CD4-induced epitope on gp120. 13th...
International Conference Maruta Y., Ramirez K., Kuwata T., Suwa Y., Morioka H., Kuwata T, Matsushita S.: Single-chain variable fragment (scFv) of anti-V3 monoclonal antibody efficiently neutralizes HIV-1 in vitro. 13th Kumamoto AIDS Seminar GCOE Joint International Symposium, 2012.10.25-26, Aso, Kumamoto.
Maruta Y., Ramirez K., Kuwata T., Suwa Y., Morioka H., Kuwata T, Matsushita S.: Single-chain variable fragment (scFv) of...
International Conference Matsushita S., Ramirez K., Maruta Y., Harada S., Maeda T., Murakami T., Kuwata T., Yoshimura K.: CCR5-inhibitor resistance confers neutralization sensitive phenotype to primary HIV-1 isolates: Implications for the passive immunotherapy of neutralizing antibodies with CCR5 inhibitors. 13th Kumamoto AIDS Seminar GCOE Joint International Symposium, 2012.10.25-26, Aso, Kumamoto
Matsushita S., Ramirez K., Maruta Y., Harada S., Maeda T., Murakami T., Kuwata T., Yoshimura K.: CCR5-inhibitor resistan...
International Conference Kuwata T., Takaki K., Enomoto, E., Matsushita S: Conformational epitope inbolving V3 and V4 loops is a major tartget for antibody-mediated neutralization in SIV smH635-infected macaques. 13th Kumamoto AIDS Seminar GCOE Joint International Symposium, 2012.10.25-26, Aso, Kumamoto, Japan.
Kuwata T., Takaki K., Enomoto, E., Matsushita S: Conformational epitope inbolving V3 and V4 loops is a major tartget for...
International Conference Maruta Y., Ramirez K., Kuwata T., Matsushita S. :Construction and characterization of neutralizing antibody fragments for efficient access to V3 epitope. AIDS Vaccine 2012, September 9-12, 2012, Boston, USA.
Maruta Y., Ramirez K., Kuwata T., Matsushita S. :Construction and characterization of neutralizing antibody fragments f...
International Conference Harada S., Arai H., Narumi T., Tamamura H., Matsushita S., Yoshimura K. In vitro induction of ten CD4 mimic small compounds, NBD-556 and its analogues, resistant variants using primary R5 HIV-1. XIX International AIDS Conference (AIDS 2012), July 22-27, Washington DC, USA.
Harada S., Arai H., Narumi T., Tamamura H., Matsushita S., Yoshimura K. In vitro induction of ten CD4 mimic small compo...
Publication Yokoyama M, Naganawa S, Yoshimura K, Matsushita S, Sato H. Structural Dynamics of HIV-1 Envelope Gp120 Outer Domain with V3 Loop. PLoS ONE. 7(5): e37530, 2012.
Yokoyama M, Naganawa S, Yoshimura K, Matsushita S, Sato H. Structural Dynamics of HIV-1 Envelope Gp120 Outer Domain with...
Publication Ong YT, Kirby KA, Hachiya A, Chiang LA, Marchand B, Yoshimura K, Murakami T, Singh K, Matsushita S, Sarafianos SG. Preparation of biological active single-chain variable antibody fragments that target the HIV-1 gp120 v3 loop. Cellular and Molecular Biology. 58: 71-79, 2012
Ong YT, Kirby KA, Hachiya A, Chiang LA, Marchand B, Yoshimura K, Murakami T, Singh K, Matsushita S, Sarafianos SG. Prepa...