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International Conference

Liu, M., Shibata, J., Harada, S., Takehisa, J., Yoshimura, K., Matsushita, S.: Impact of a point mutation V2 (L175P) in neutralization resistance mediated by functional trimer formation of Env. AIDS Vaccine 2010, Sep.28-Oct.1, 2010. Atlanta, USA.

Liu, M., Shibata, J., Harada, S., Takehisa, J., Yoshimura, K., Matsushita, S.: Impact of a point mutation V2 (L175P) in ...
International Conference

Matsushita, S., Mouri, S., Harada, S., Yamada, Y., Tamamura, H., Yoshimura, K.: CD4 mimetic compound-mediated enhancement of the neutralization activities of anti-V3 and CD4i monoclonal antibodies against the standard panel of primary isolates. XVIII International AIDS Conference. July.18-23, 2010. Vienna, Austria.

Matsushita, S., Mouri, S., Harada, S., Yamada, Y., Tamamura, H., Yoshimura, K.: CD4 mimetic compound-mediated enhancemen...
Publication

4. Narumi, T., Ochiai, C., Yoshimura, K., Harada, S., Tanaka,T., Nomura,W., Arai, H., Ozaki, T., Ohashi, N., Matsushita, S., Tamamura, H. :CD4mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist. Bioorganic & Medicinal Chemistry Letters. 5853- 5858, 2010.

Narumi, T., Ochiai, C., Yoshimura, K., Harada, S., Tanaka,T., Nomura,W., Arai, H., Ozaki, T., Ohashi, N., Matsushita, S....
2010

Yoshimura, K., Harada, S., Shibata, J., Hatada, M., Yamada, Y., Ochiai, C., Tamamura, H., Matsushita, S. :Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds. J. Virol. 84:7558-7568, 2010.

Yoshimura, K., Harada, S., Shibata, J., Hatada, M., Yamada, Y., Ochiai, C., Tamamura, H., Matsushita, S. :Enhanced expos...
Publication

Hatada, M., Yoshimura, K., Harada, S., Kawanami, Y., Shibata, J., Matsushita S. HIV-1 evasion of a neutralizing anti-V3 antibody involves acquisition of a potential glycosylation site in V2. J. Gen. Virol. 91: 1335-1345, 2010. 

Hatada, M., Yoshimura, K., Harada, S., Kawanami, Y., Shibata, J., Matsushita S. HIV-1 evasion of a neutralizing anti-V3 ...
Publication

Yamada, Y., Ochiai, C., Yoshimura, K., Tanaka, T., Ohashi, N., Narumi, T., Nomura, W., Harada, S., Matsushita, S., Tamamura, H. CD4 mimics targeting the mechanism of HIV entry. Bioorganic & Medicinal Chemistry Letters 20: 354–358, 2010.

Yamada, Y., Ochiai, C., Yoshimura, K., Tanaka, T., Ohashi, N., Narumi, T., Nomura, W., Harada, S., Matsushita, S., Tamam...
International Conference

Harada S., Yoshimura K., Kawanami Y., Matsushita S. In vitro selections of raltegravir resistant variants using diverse primary isolates, subtype B, C, CRF01_AE, and CRF08_BC. 2010 IYIS, 2010.3.4-5, Kumamoto, Japan.

Harada S., Yoshimura K., Kawanami Y., Matsushita S. In vitro selections of raltegravir resistant variants using diverse ...
International Conference

Yoshimura K., Harada S., Matsushita S. Two step escape pathway of the HIV-1 subtype C primary isolate induced by the in vitro selection of Maraviroc. 17th Conference on Retroviruses and Opportunistic Infections (CROI 2010), 2010.2.16-19, San Francisco, USA.

Yoshimura K., Harada S., Matsushita S. Two step escape pathway of the HIV-1 subtype C primary isolate induced by the in ...
Domestic Conference

石川哲也,畑田万紀子,原田 恵嘉,吉村和久, 松下修三: 実験室HIV-1 R5株を用いたin vitro CCR5阻害薬 (maraviroc) 耐性ウイルス誘導の試み第23回日本エイズ学会学術集会・総会.  2009.11.26-28 名古屋

石川哲也,畑田万紀子,原田 恵嘉,吉村和久, 松下修三: 実験室HIV-1 R5株を用いたin vitro CCR5阻害薬 (maraviroc) 耐性ウイルス誘導の試み第23回日本エイズ学会学術集会・総会.  2009.11.26-28 ...
Domestic Conference

原田 恵嘉,吉村和久, 松下修三: 最近分離した7種の臨床HIV-1株を用いたin vitro ラルテグラビル耐性ウイルス誘導.  第23回日本エイズ学会学術集会・総会.  2009.11.26-28 名古屋

原田 恵嘉,吉村和久, 松下修三: 最近分離した7種の臨床HIV-1株を用いたin vitro ラルテグラビル耐性ウイルス誘導.  第23回日本エイズ学会学術集会・総会.  2009.11.26-28 名古屋
Domestic Conference

吉村和久: ケモカインレセプター阻害剤の臨床的研究〜臨床分離株を用いたマラビロック耐性誘導〜. 第23回に本エイズ学会学術集会・総会.  2009.11.26-28 名古屋

吉村和久: ケモカインレセプター阻害剤の臨床的研究〜臨床分離株を用いたマラビロック耐性誘導〜. 第23回に本エイズ学会学術集会・総会.  2009.11.26-28 名古屋
Domestic Conference

松下修三:エンベロープの進化と中和抗体. シンポジウムHIV細胞侵入とその防御機構. 第23回日本エイズ学会学術集会・総会.  2009.11.26-28 名古屋

松下修三:エンベロープの進化と中和抗体. シンポジウムHIV細胞侵入とその防御機構. 第23回日本エイズ学会学術集会・総会.  2009.11.26-28 名古屋
Domestic Conference

畑田万紀子、吉村和久、原田惠嘉、松下修三:抗HIV-1V3抗体からの逃避過程で挿入される V2領域の糖鎖が保存されるメカニズム-HIV-1の進化における耐性度と増殖能のバランスに関する考察- 第57回日本ウイルス学会学術集会. 2009.10.25-27 東京.

畑田万紀子、吉村和久、原田惠嘉、松下修三:抗HIV-1V3抗体からの逃避過程で挿入される V2領域の糖鎖が保存されるメカニズム-HIV-1の進化における耐性度と増殖能のバランスに関する考察- 第57回日本ウイルス学会学術集会. 2009.1...
International Conference

Narahara C, Hatada M, Harada S., Yoshimura, K,. Matsushita S,: A primary R5 isolate undergoes different escape pathway during in vitro selection with low or high concentration of an anti-V3 monoclonal antibody. AIDS Vaccine 2009, 2009.10.19-22, Paris.

Narahara C, Hatada M, Harada S., Yoshimura, K,. Matsushita S,: A primary R5 isolate undergoes different escape pathway...
International Conference

Matsushita S: Accumulation of multiple functional mutations in HIV-1 gp120 is involved in the development of neutralization escape under pressure of neutralizing antibody in vitro. Kumamoto AIDS Seminar GCOE Joint International Symposium- Satellite Symposium, 2009.9.30, Aso, Kumamoto.

Matsushita S: Accumulation of multiple functional mutations in HIV-1 gp120 is involved in the development of neutralizat...
International Conference

Yoshimura K, Matsushita S: In vitro induction of HIV-1 resistant to a CCR5. Kumamoto AIDS Seminar GCOE Joint International Symposium- Satellite Symposium, 2009.9.30, Aso, Kumamoto

Yoshimura K, Matsushita S: In vitro induction of HIV-1 resistant to a CCR5. Kumamoto AIDS Seminar GCOE Joint Internation...
International Conference

Matsushita S. Narahara C, Nishida Y, Honda A., Harada S., Yoshimura K.: Polyclonal antibody response against gp120 including antibodies to V3, CD4bs and CD4i epitopes account or broad neutralization. 10th Kumamoto AIDS Seminar GCOE Joint International Symposium. 2009.9.28-29, Kumamoto.

Matsushita S. Narahara C, Nishida Y, Honda A., Harada S., Yoshimura K.: Polyclonal antibody response against gp120 incl...
International Conference

Hatada M. Yoshimura K., Harada S, and Matsushita S.:Mechanism of maintaining a glycan-insertion in HIV-1 gp120 V2 region under pressure of a potent neutralizing antibody in vitro. 10th Kumamoto AIDS Seminar GCOE Joint International Symposium. 2009.9.28-29, Kumamoto.

Hatada M. Yoshimura K., Harada S, and Matsushita S.:Mechanism of maintaining a glycan-insertion in HIV-1 gp120 V2 region...
International Conference

Ishikawa T., Yoshimura K., Hatada M. Harada S, and Matsushita S.: Mutations in gp120 of R5 HIV-1 laboratory isolate induced by the in vitro selection of maraviroc confer highly sensitive to anti-V3 monoclonal antibody. 10th Kumamoto AIDS Seminar GCOE Joint International Symposium. 2009.9.28-29, Kumamoto

Ishikawa T., Yoshimura K., Hatada M. Harada S, and Matsushita S.: Mutations in gp120 of R5 HIV-1 laboratory isolate indu...
International Conference

Yoshimura K., Harada S, Hatada M. and Matsushita S.: In vitro induction of HIV-1 resistant to a CCR5 antagonist maraviroc. 10th Kumamoto AIDS Seminar GCOE Joint International Symposium. 2009.9.28-29, Kumamoto

Yoshimura K., Harada S, Hatada M. and Matsushita S.: In vitro induction of HIV-1 resistant to a CCR5 antagonist maraviro...
International Conference

Harada S, Yoshimura K., and Matsushita S.: Generation of an integrase inhibitor raltegravir resistant variants using recent primary isolates, X4, R5 and dual/mix HIV-1. 10thKumamoto AIDS Seminar GCOE Joint International Symposium. 2009.9.28-29, Kumamoto

Harada S, Yoshimura K., and Matsushita S.: Generation of an integrase inhibitor raltegravir resistant variants using rec...
International Conference

Matsushita S, Narahara C, Morizono M, Nishida Y, Honda-Shibata A, Harada S, Yoshimura K: Polyclonal antibody response against gp120 including antibodies to V3, CD4bs and CD4i eppitopes account or broad neutralizaion. 5th Conference on HIV Pathogenesis, Treatment and prevention. 2009.7.19-22,Cape Town,South Africa

Matsushita S, Narahara C, Morizono M, Nishida Y, Honda-Shibata A, Harada S, Yoshimura K: Polyclonal antibody response ag...
Domestic Conference

松下修三:HIV-1に対する中和単クローン抗体の治療応用に向けた基礎研究. 第9回日本蛋白質化学学会 2009.5.20-22. 熊本

松下修三:HIV-1に対する中和単クローン抗体の治療応用に向けた基礎研究. 第9回日本蛋白質化学学会 2009.5.20-22. 熊本
International Conference

Yoshimura, K, Harada S., Hatada, M., Matsushita S.:Mutations in V4 and C4 regions of the HIV-1 CRF-BC envelope induced by the in vitro selection of Maraviroc Confer cross-resistance to other CCR5 inhibitors. 16th Conference on Trtroviruses and Opportunistic Infections(CROI 2009). 20092..8-11, Montreal, Canada

Yoshimura, K, Harada S., Hatada, M., Matsushita S.:Mutations in V4 and C4 regions of the HIV-1 CRF-BC envelope induced b...
Domestic Conference

楢原知里、吉村和久、畑田万紀子、原田恵嘉、松下修三:中和抗体高感受性R5臨床分離株の抗V3抗体によるin vitro中和逃避ウイルス誘導. 第22回日本エイズ学会学術集会・総会.  2008.11.26-11.28. 大阪

楢原知里、吉村和久、畑田万紀子、原田恵嘉、松下修三:中和抗体高感受性R5臨床分離株の抗V3抗体によるin vitro中和逃避ウイルス誘導. 第22回日本エイズ学会学術集会・総会.  2008.11.26-11.28. 大阪
Domestic Conference

畑田万紀子、吉村和久、石川哲也、原田恵嘉、松下修三: V2領域のN-glycosylation site挿入が抗V3中和抗体エスケープに及ぼす影響. 第22回日本エイズ学会学術集会・総会.  2008.11.26-11.28. 大阪

畑田万紀子、吉村和久、石川哲也、原田恵嘉、松下修三: V2領域のN-glycosylation site挿入が抗V3中和抗体エスケープに及ぼす影響. 第22回日本エイズ学会学術集会・総会.  2008.11.26-11.28. 大阪
Domestic Conference

吉村和久、原田恵嘉、畑田万紀子、増野弘幸、玉村啓和、松下修三: CD4 mimic small compoundのin vitro耐性誘導による結合部位の予測. 第22回日本エイズ学会学術集会・総会.  2008.11.26-11.28. 大阪

吉村和久、原田恵嘉、畑田万紀子、増野弘幸、玉村啓和、松下修三: CD4 mimic small compoundのin vitro耐性誘導による結合部位の予測. 第22回日本エイズ学会学術集会・総会.  2008.11.26-11.28. ...
International Conference

Narahara, C., Yoshimura, K, Hatada, M., Harada, S., Matsushita S.: Different mutation in HIV-1 gp120 V3-tip regin for escape from a potent neutralizing anti-V3 monoclonal antibody during in vitro selection with low or high concentration of the Mab. 9th Kumamoto AIDS Seminar. Sep. 18-19, 2008, Aso, Kumamoto.

Narahara, C., Yoshimura, K, Hatada, M., Harada ,S., Matsushita, S.: Different mutation in HIV-1 gp120 V3-tip regin for e...
International Conference

Hatada, M., Yoshimura, K, Ishikawa T., Harada S., Matsushita S.: The impact of an N-linked glycosylation site insertion in HIV-1 gp120 region to escape from a potent neutralization anti-V3 monoclonal antibody. 9th Kumamoto AIDS Seminar. Sep. 18-19, 2008, Aso, Kumamoto.

Hatada, M., Yoshimura, K, Ishikawa T., Harada S., Matsushita S.: The impact of an N-linked glycosylation site insertion ...
International Conference

Yoshimura, K, Hatada, M., Harada S., Shibata J., Masuo, H., Tamamura, H., Matsushita S.: In vitro induction of human immunodeficienby virus type 1 variants resistant to a low-molecular CD4 mimic compound. 9th Kumamoto AIDS Seminar. Sep. 18-19, 2008, Aso, Kumamoto

Yoshimura, K, Hatada, M., Harada S., Shibata J., Masuo, H., Tamamura, H., Matsushita S.: In vitro induction of human imm...
Publication

Ryo, A., Tsurutani, N., Ohba, K., Kimura, R., Komano, J., Nishi, M., Soeda, H., Hattori,S., , Perrem, K., Yamamoto, M., Chiba, J., Mimaya, J., Yoshimura, K., Matsushita, S., Honda, M., Yoshimura, A., Sawasaki, T., Aoki, I., Morikawa, Y., and Yamamoto, N. SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag. Proc Natl Acad Sci U S A. 105:294-299, 2008.

Ryo, A., Tsurutani, N., Ohba, K., Kimura, R., Komano, J., Nishi, M., Soeda,H., Hattori,S., Perrem, K., Yamamoto, M., Chi...
Publication

Ikeda T, Ohsugi T, Kimura T, Matsushita S., Maeda Y, Harada S, Koito A. The anti-retroviral potency of APOBEC1 deaminase from small animal species. Nuleic Acids Research, 36(21): 6859-6871, 2008.

Ikeda T, Ohsugi T, Kimura T, Matsushita S., Maeda Y, Harada S, Koito A. The anti-retroviral potency of APOBEC1 deaminase...
International Conference

Yoshimura, K, Shibata J., Honda, A., Yamada, Y., Nasuo, H., Tamamura, H., Matsushita S.:In vitro induction of human immunodeficienby virus type 1 variants resistant to a low-molecular CD4 mimic compound, N- (4- Chlorophenyl) -N’ – (2,2,6,6-tetramethylpiperidin- 4-yl) – oxalamide (NBD-556). 15th Conference on Retroviruses and Opportunistic infections. Feb. 3-6, 2008, Boston, USA.

Yoshimura, K, Shibata J., Honda, A., Yamada, Y., Nasuo, H., Tamamura, H., Matsushita S.:In vitro induction of human immu...
International Conference

Matsushita S., Nishida, Y., Shibata J., Honda A., Yoshimura, K: Broad cross-neutralization mediated by combination of anti-V3 and CD4 binding site antibodies in an HIV-1 infected patient with long-term non-progressie disease. 15th Conference on Retroviruses and Opportunistic infections. Feb. 3-6, 2008, Boston, USA

Matsushita S., Nishida, Y., Shibata J., Honda A., Yoshimura, K: Broad cross-neutralization mediated by combination of an...
Domestic Conference

吉村和久、柴田潤二、畑田万紀子、山田裕子、増野弘幸、玉村啓和、松下修三:CD4 mimic small compoundとanti-HIV monoclonal antibodyのウイルス中和における相乗効果。第21回日本エイズ学会学術集会・総会. 2007.11.28-11.30. 広島.

吉村和久、柴田潤二、畑田万紀子、山田裕子、増野弘幸、玉村啓和、松下修三:CD4 mimic small compoundとanti-HIV monoclonal antibodyのウイルス中和における相乗効果。第21回日本エイズ学会学術集会...
Domestic Conference

柴田潤二、吉村和久、松下修三:中和抗体高度抵抗性ウイルスを感受性にする変異はgp120三量体構造に影響を与える。第21回日本エイズ学会学術集会・総会. 2007.11.28-11.30. 広島.

柴田潤二、吉村和久、松下修三:中和抗体高度抵抗性ウイルスを感受性にする変異はgp120三量体構造に影響を与える。第21回日本エイズ学会学術集会・総会. 2007.11.28-11.30. 広島.
Domestic Conference

畑田万紀子,吉村和久,柴田潤二,松下修三:強力な抗HIV-1 gp120-V3抗体KD-247に対するHIV-1BaLの中和逃避のメカニズム解析. 第21回日本エイズ学会学術集会・総会. 2007.11.28-11.30. 広島.

畑田万紀子,吉村和久,柴田潤二,松下修三:強力な抗HIV-1 gp120-V3抗体KD-247に対するHIV-1BaLの中和逃避のメカニズム解析. 第21回日本エイズ学会学術集会・総会. 2007.11.28-11.30. 広島.
Domestic Conference

松下修三、西田吉辰、柴田潤二、畑田万紀子、吉村和久,: 長期非進行症例(LTNP)における交叉中和のメカニズムの研究 I; 中和単クローン抗体の作成と解析. 第21回日本エイズ学会学術集会・総会. 2007.11.28-11.30. 広島.

松下修三、西田吉辰、柴田潤二、畑田万紀子、吉村和久,: 長期非進行症例(LTNP)における交叉中和のメカニズムの研究 I; 中和単クローン抗体の作成と解析. 第21回日本エイズ学会学術集会・総会. 2007.11.28-11.30. 広島.
International Conference

Matsushita S.:Development of broadly reactive neutralizing monoclonal antibody KD-247: implications for passive immunotherapy. Tentative Program for the 3rd Japan-Germany HIV/AIDS Symposium. Nov. 26, 2007. Hiroshima.

Matsushita S.:Development of broadly reactive neutralizing monoclonal antibody KD-247: implications for passive immunoth...
International Conference

Yoshimura, K., Shibata, J., Honda A., Tamamura, H., and Matsushita S.: A potent neutralizing anti-V3 monoclonal antibody, KD-247 shows favorable synergism with other antiretrovirals, sCD4 and CD4 mimic small compound in vitro. 8th AIDS Seminar in Kumamoto. Sep 13-14, 2007. Aso, Kumamoto.

Yoshimura, K., Shibata, J., Honda A., Tamamura, H., and Matsushita S.: A potent neutralizing anti-V3 monoclonal antibo...
International Conference

Hatada, M., Yoshimura K, Shibata J, Matsushita S. HIV-1BaL mutants escaping neutralization from a potent neutralizing anti-V3 monoclonal antibody KD-247. . 8th AIDS Seminar in Kumamoto. Sep 13-14, 2007. Aso, Kumamoto.

Hatada, M., Yoshimura K, Shibata J, Matsushita S. HIV-1BaL mutants escaping neutralization from a potent neutralizing an...
International Conference

Shibata J, Yoshimura K, Matsushita S. :The single mutation in V2 domain affects quaternary structure of trimer gp120 and dramatically increases the sensitivity of primary human immunodeficiency virus type 1 isolates to neutralizing antibodies. 8th AIDS Seminar in Kumamoto. Sep 13-14, 2007. Aso, Kumamoto.

Shibata J, Yoshimura K, Matsushita S. :The single mutation in V2 domain affects quaternary structure of trimer gp120 and...
International Conference

Nishida,Y., Shibata, J., Yoshimura K., and Matsushita,S.: Broad neutralization against the HIV-1 subtype B panel of reference strains by human monoclonal antibodies established from an HIV-1infected long-term non-progressor. 8th AIDS Seminar in Kumamoto. Sep 13-14, 2007. Aso, Kumamoto.

Nishida,Y., Shibata, J., Yoshimura K., and Matsushita,S.: Broad neutralization against the HIV-1 subtype B panel of refe...
International Conference

Yoshimura K, Shibata J, Honda A,Koito A, Matsushita S. A potent neutralizing anti-V3 monoclonal antibody, KD-247 shows faborable synergism with other antiretrovirals,sCD4 and CD4 mimic small compound in vitro. The 4th IAS conference on HIV Pathogenesis, Treatment and Prevension, July 22-25, 2007

Yoshimura K, Shibata J, Honda A,Koito A, Matsushita S. A potent neutralizing anti-V3 monoclonal antibody, KD-247 shows f...
Domestic Conference

Matsushita S, Ikeda T, Shibata J, Koito K, Yoshimura K. Identification of integration sited of HIV-1 provirus; A possible target for the gene therapy for AIDS. 第13回日本遺伝子治療学会.2007.6.28-29、名古屋

Matsushita S, Ikeda T, Shibata J, Koito K, Yoshimura K. Identification of integration sited of HIV-1 provirus; A possibl...
International Conference

Matsushita S., Ikeda, T, Shibata J., Honda A., Koito K, Yoshimura. K. Persistence of proviral DNA and the integration sites of HIV-1 in patients on prolonged and effective HAART. 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Sydney, Australia. June. 22-25, 2007.

Matsushita S., Ikeda, T, Shibata J., Honda A., Koito K, Yoshimura. K. Persistence of proviral DNA and the integration si...
Publication

Ikeda T, Shibata J, Yoshimura K,Koito A, Matsushita S. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective HAART.J. Infect. Dis.195:716-725, 2007 .

Ikeda T, Shibata J, Yoshimura K,Koito A, Matsushita S. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T ...
Publication

Shibata J, Yoshimura K, Honda A.,Koito A, Murakami T. Matsushita S. Impact of V2 mutations for escape from a potent neutralizing anti-V3 monoclonal antibody during in vitro selection of a primary HIV-1 isolate. J. Virol. 81:3757-3768,2007

Shibata J, Yoshimura K, Honda A.,Koito A, Murakami T. Matsushita S. Impact of V2 mutations for escape from a potent neut...
Publication

Gatanaga H, Hayashida T, Tsuchiya K, Yoshino M, Kuwahara T, Tsukada H, Fujimoto K, Sato I, Ueda M, Horiba M, Hamaguchi M, Yamamoto M, Takata N, Kimura A, Koike T, Gejyo F, Matsushita S, Shirasaka T, Kimura S, Oka S.: Successful efavirenz dose reduction in HIV-1-infeccted individuals with cytochrome P450 2B6*6 and *26. Clinical Infectious Diseases., 45: 1230-1237, 2007.

Gatanaga H, Hayashida T, Tsuchiya K, Yoshino M, Kuwahara T, Tsukada H, Fujimoto K, Sato I, Ueda M, Horiba M, Hamaguchi M...
Publication

Nakayama E.E., Carpentier W, Costagliola D., Shioda T., Iwamoto A., Debre P, Yoshimura K, Autran B, Matsushita S, Theodorou I. Wild type and H43Y variant of human TRIM5α show similar anti-human immunodeficiency virus type 1 activity both in vivo and in vitro. Immunogenetics 59:511-515, 2007.

Nakayama E.E., Carpentier W, Costagliola D., Shioda T., Iwamoto A., Debre P, Yoshimura K, Autran B, Matsushita S, Theodo...
Domestic Conference

松下修三. シンポジウム3「より良いHAARTに向けて」-耐性検査の意義とタイミング.  第20回日本エイズ学会学術集会・総会. 2006.11.30-12.2. 東京.

松下修三. シンポジウム3「より良いHAARTに向けて」-耐性検査の意義とタイミング.  第20回日本エイズ学会学術集会・総会. 2006.11.30-12.2. 東京.
Domestic Conference

吉村和久、柴田潤二、小糸 厚、松下修三. In vitroにおける抗HIV-1中和単クローン抗体とその他の薬剤との相互作用の研究. 第20回日本エイズ学会学術集会・総会. 2006.11.30-12.2. 東京.

吉村和久、柴田潤二、小糸 厚、松下修三. In vitroにおける抗HIV-1中和単クローン抗体とその他の薬剤との相互作用の研究. 第20回日本エイズ学会学術集会・総会. 2006.11.30-12.2. 東京.
Domestic Conference

柴田潤二、吉村和久、小糸 厚、松下修三. 抗HIV-1 gp120-V3抗体より逃避したV2領域変異ウイルスの中和抵抗性メカニズムの解析. 第54回日本ウイルス学会総会. 2006.11.18-21. 名古屋

柴田潤二、吉村和久、小糸厚、松下修三. 抗HIV-1 gp120-V3抗体より逃避したV2領域変異ウイルスの中和抵抗性メカニズムの解析. 第54回日本ウイルス学会総会. 2006.11.18-21. 名古屋
Domestic Conference

池田輝政、柴田潤二、吉村和久、小糸 厚、松下修三. 長期間HAART有効症例における残存HIVと組込み部位の関連性. 第54回日本ウイルス学会総会. 2006.11.18-21. 名古屋

池田輝政、柴田潤二、吉村和久、小糸 厚、松下修三. 長期間HAART有効症例における残存HIVと組込み部位の関連性. 第54回日本ウイルス学会総会. 2006.11.18-21. 名古屋
International Conference

Yoshimura K, Shibata J, Honda A, Koito A, Matsushita S. A novel potent neutralizing anti-V3 monoclonal antibody, KD-247, that shows faborable synergism with anti-CCR5 inhibitors in vitro. 7th AIDS Seminar in Kumamoto, Sep 21-22, 2006.

Yoshimura K, Shibata J, Honda A, Koito A, Matsushita S. A novel potent neutralizing anti-V3 monoclonal antibody, KD-247,...
International Conference

Shibata J, Yoshimura K, Honda A, Koito A, Murakami T, Matsushita S. Impact of V2 mutations for escape from a potent neutralizing anti-V3 monoclonal antibody during in vitro selection of a primary HIV-1 isolate. 7th AIDS Seminar in Kumamoto, Sep 21-22, 2006

Shibata J, Yoshimura K, Honda A, Koito A, Murakami T, Matsushita S. Impact of V2 mutations for escape from a potent neut...
International Conference

Ikeda T, Shibata J, Yoshimura K, Koito A, Matsushita S. Recurrent HIV-1 integration at BACH2 locus in resting CD4+ T cell populations during effective HAART. 7th AIDS Seminar in Kumamoto, Sep 21-22, 2006.

Ikeda T, Shibata J, Yoshimura K, Koito A, Matsushita S. Recurrent HIV-1 integration at BACH2 locus in resting CD4+ T cel...
International Conference

Matsushita S., Shibata J., Honda A., Murakami T, Eda Y, Koito A, Yoshimura . Development of broadly immunotherapy. AIDS Vaccine 2006 Conference, Amsterdam, the Netherlands, Aug. 29-Sep.1, 2006.

Matsushita S., Shibata J., Honda A., Murakami T, Eda Y, Koito A, Yoshimura . Development of broadly immunotherapy. AIDS ...
Publication

Eda Y, Takizawa M, Murakami T., Maeda H., Kimachi K., YonemuraH, Koyanagi S, Shiosaki K, Higuchi H, Makizumi K, Nakashima T ,Osatomi K., Tokiyoshi S, Matsushita S, Yamamoto N. Honda M. Sequential immunization with V3 peptides from primary HIV-1 produces cross-neutralizing antibodies against primary isolates with matching narrow neutralization sequence motif.J. Virol. 80:5552-5562,2006.

Eda Y, Takizawa M, Murakami T., Maeda H., Kimachi K., YonemuraH, Koyanagi S, Shiosaki K, Higuchi H, Makizumi K, Nakashim...
Publication

Eda Y, Murakami T, Ami Y, Nakasone T, Takizawa M, Someya K, Kaizu M, Izumi Y., Yoshino, N., Matsusita, S.,Higuchi, H., Matsui, H., Shinohara, K., Takeuchi, H., Koyanagi, S., Yamamoto, N. and Honda M. Anti-V3 humanized antibody KD-247 effectively suppresses ex vivo generation of human immunodeficiency virus type 1 and affordssterile protection of monkeys against a heterologous simian/human immunodeficiency virus infection. J. Virol. 80:5563-5570, 2006

Eda Y, Murakami T, Ami Y, Nakasone T, Takizawa M, Someya K, Kaizu M, Izumi Y., Yoshino, N., Matsusita, S.,Higuchi, H., M...
Publication

Davis DA, Brown CA, Singer KE., Wang V, Kaufman J, Stahl SJ, Wingfield P, Maeda K, Harada S, Yoshimura K, Kosalaraksa, P, Mitsuya H, Yarchoan R Antiviral Res. 72:89-99, 2006

Davis DA, Brown CA, Singer KE., Wang V, Kaufman J, Stahl SJ, Wingfield P, Maeda K, Harada S, Yoshimura K, Kosalaraksa, P...
Publication

Yoshimura K, Shibata J, Kimura T, Honda A, Maeda Y, Koito A, Murakami T, Mitsuya H, Matsushita S. Resistance profile of a neutralizing anti-HIV monoclonal antibody, KD-247, that shows favorable synergism with anti-CCR5 inhibitors. AIDS .20:2065-2073, 2006.

Yoshimura K, Shibata J, Kimura T, Honda A, Maeda Y, Koito A, Murakami T, Mitsuya H, Matsushita S. Resistance profile of ...
International Conference

Yoshimura, K., Shibata, J., Honda A., Murakami,T., Mitsuya,H., Koito, A., and Matsushita S.: Resistance Profile of A Novel Broadly Neutralizing Anti-HIV Monoclonal Antibody, KD-247 That Has Favorable Synergism with Anti-CCR5 Inhibitors In Vitro.13th Conference on Retroviruses and Opportunistic Infections. Denver, USA, Feb.4-9, 2006.

Yoshimura, K., Shibata, J., Honda A., Murakami,T., Mitsuya,H., Koito, A., and Matsushita S.: Resistance Profile of A Nov...
International Conference

Shibata, J., Yoshimura, K., Honda A., Murakami,T., Koito, A., and Matsushita S.: A Role of Mutations in Non-V3 Envelope Regions for Escape from a Broad Neutralizing Anti-V3 Monoclonal Antibody, KD-247, during in vitro Selection. 13th Conference on Retroviruses and Opportunistic Infections. Denver, USA, Feb.4-9, 2006

Shibata, J., Yoshimura, K., Honda A., Murakami,T., Koito, A., and Matsushita S.: A Role of Mutations in Non-V3 Envelope ...
International Conference

Matsushita S., Honda A., Shibata, J., Kimura T., Ikeda, T., Koito, A., Yoshimura, K.: HIV-1 proviral DNA dynamics in patients with long-term successful HAART. 2nd International Workshop on HIV Persistence during Therapy. 12. 6-9, 2005, Saint Martin, FWI.

Matsushita S., Honda A., Shibata, J., Kimura T., Ikeda, T., Koito, A., Yoshimura, K.: HIV-1 proviral DNA dynamics in pat...
Domestic Conference

池田輝政、柴田潤二、吉村和久、小糸厚、松下修三:長期間HAART有効症例における残存HIVとintegration siteの関連性. 第19回日本エイズ学会学術集会. 2005.12.1-3. 熊本.

池田輝政、柴田潤二、吉村和久、小糸厚、松下修三:長期間HAART有効症例における残存HIVとintegration siteの関連性. 第19回日本エイズ学会学術集会. 2005.12.1-3. 熊本.
Domestic Conference

柴田潤二、吉村和久、前田洋助、村上俊夫、小糸厚、松下修三:広範囲HIV-1中和単クローン抗体のin vitro逃避ウイルスの誘導と解析. 第19回日本エイズ学会学術集会. 2005.12.1-3. 熊本.

柴田潤二、吉村和久、前田洋助、村上俊夫、小糸厚、松下修三:広範囲HIV-1中和単クローン抗体のin vitro逃避ウイルスの誘導と解析. 第19回日本エイズ学会学術集会. 2005.12.1-3. 熊本.
Domestic Conference

吉村和久、柴田潤二、池田輝政、小糸厚、松下修三:HAARTにより長期間ウイルスが抑制された症例のpDNAの推移. 第19回日本エイズ学会学術集会. 2005.12.1-3. 熊本.

吉村和久、柴田潤二、池田輝政、小糸厚、松下修三:HAARTにより長期間ウイルスが抑制された症例のpDNAの推移. 第19回日本エイズ学会学術集会. 2005.12.1-3. 熊本.
Domestic Conference

松下修三:シンポジウム-HIV/AIDSの臨床における最近の問題点-イントロダクションー.第19回日本エイズ学会学術集会.  2005.12.1-3. 熊本.

松下修三:シンポジウム-HIV/AIDSの臨床における最近の問題点-イントロダクションー.第19回日本エイズ学会学術集会.  2005.12.1-3. 熊本.
Domestic Conference

柴田潤二、吉村和久、小糸 厚、松下修三 : ヒト免疫不全ウイルス1型gp120のC3領域変異による抗V3中和抗体に対する中和抵抗性の獲得. 第53回日本ウイルス学会総会、横浜、2005.11.20-22.

柴田潤二、吉村和久、小糸 厚、松下修三 : ヒト免疫不全ウイルス1型gp120のC3領域変異による抗V3中和抗体に対する中和抵抗性の獲得. 第53回日本ウイルス学会総会、横浜、2005.11.20-22.
Domestic Conference

柴田潤二、吉村和久、前田洋助、村上利夫、江田康幸、小糸厚、松下修三: 広範囲HIV-1単クローン抗体のin vitro逃避ウイルスの誘導と解析.第8回白馬シンポジウムin鹿児島-エイズ治療の最前線-.2005.11.3-4.鹿児島.

柴田潤二、吉村和久、前田洋助、村上利夫、江田康幸、小糸厚、松下修三: 広範囲HIV-1単クローン抗体のin vitro逃避ウイルスの誘導と解析.第8回白馬シンポジウムin鹿児島-エイズ治療の最前線-.2005.11.3-4.鹿児島.
Domestic Conference

松下修三:A broadly reactive neutralizing antibody and evolution of escape mutants in vitro. 第8回白馬シンポジウムin鹿児島?エイズ治療の最前線?.2005.11.3-4.鹿児島.

松下修三:A broadly reactive neutralizing antibody and evolution of escape mutants in vitro. 第8回白馬シンポジウムin鹿児島?エイズ治療の最前線?.2005...
Domestic Conference

柴田潤二、吉村和久、前田洋助、村上利夫、江田康幸、小糸厚、松下修三: 広範囲HIV-1単クローン抗体のin vitro逃避ウイルスの誘導と解析. 第6回熊本エイズセミナー. 2005.9.15. 熊本.

柴田潤二、吉村和久、前田洋助、村上利夫、江田康幸、小糸厚、松下修三: 広範囲HIV-1単クローン抗体のin vitro逃避ウイルスの誘導と解析. 第6回熊本エイズセミナー. 2005.9.15. 熊本.
International Conference

Ikeda, T., Shibata, J., Honda A., Yoshimura K., Koito, A., Matsushita, S.: Relationship of residual HIV-1 and the integration sites in patients on prolonged and effective HAART. International Symposium, The Cooperative research Project on Clinical and Epidemiological Studies of Emerging and Re-emerging Infectious Diseases, 2005. 9.15-16. Kumamoto.

Ikeda, T., Shibata, J., Honda A., Yoshimura K., Koito, A., Matsushita, S.: Relationship of residual HIV-1 and the integr...
International Conference

Shibata, J., Yoshimura K., Maeda, Y., Murakami, T., Eda. Y., Koito, A., Matsushita, S.: In vitro induction of human immunodeficiency virus type 1 variants resistant to a novel broad neutralizing anti-HIV monoclonal antibody, KD-247. International Symposium, The Cooperative research Project on Clinical and Epidemiological Studies of Emerging and Re-emerging Infectious Diseases, 2005. 9.15-16. Kumamoto.

Shibata, J., Yoshimura K., Maeda, Y., Murakami, T., Eda. Y., Koito, A., Matsushita, S.: In vitro induction of human immu...
International Conference

Yoshimura K., Shibata, J., Ikeda, T., Honda A., Koito, A., Matsushita, S.: HIV-1 proviral DNA dynamics in patients with long-term successful HAART. International Symposium, The Cooperative research Project on Clinical and Epidemiological Studies of Emerging and Re-emerging Infectious Diseases, 2005. 9.15-16. Kumamoto.

Yoshimura K., Shibata, J., Ikeda, T., Honda A., Koito, A., Matsushita, S.: HIV-1 proviral DNA dynamics in patients with ...
International Conference

Matsushita S., Shibata, J., Yoshimura, K., Maeda,Y., Murakami,T., Koito A, Honda, M., Mitsuya,H., Eda, Y. : Development of broadly reactive neutralizing monoclonal antibody KD247: implication for passive immunotherapy. The cooperative research project on clinical and epidemiological studies of emerging and re-emerging infectious diseases, Aso, Japan, Sep. 15-16, 2005.

Matsushita S., Shibata, J., Yoshimura, K., Maeda,Y., Murakami,T., Koito A, Honda, M., Mitsuya,H., Eda, Y. : Development...
International Conference

Matsushita, S., Honda A., Kenai, A., Shibata, J., Koito, A., Yoshimura K.: Long-Term Follow-Up Study for the Change of the Reservoir for HIV-1 on Highly Active Antiretroviral Therapy. 7th International Congress on AIDS in Asia and the Pacific. 2005. 7. 1-5. Kobe.

Matsushita, S., Honda A., Kenai, A., Shibata, J., Koito, A., Yoshimura K.: Long-Term Follow-Up Study for the Change of t...
International Conference

Yoshimura K., Honda A., Kenai, A., Shibata, J., Koito, A., Matsushita, S.: Proviral DNA and Turnover Levels in Aviremic Long-Term Non-Progressors (LTNPs); A Temporary Goal forreactive neutralizing monoclonal antibody KD247: implicat5ions for passivePatients under HAART. 7th International Congress on AIDS in Asia and the Pacific. 2005. 7. 1-5. Kobe.児島.

Yoshimura K., Honda A., Kenai, A., Shibata, J., Koito, A., Matsushita, S.: Proviral DNA and Turnover Levels in Aviremic ...
Publication

Matsushita S., Yoshimura, K., Kimura T., Kamihira, A., Takano, M., Eto, K., Shirasaka, T., Mitsuya, H., Oka, S.: Spontaneous recovery of hemoglobin and neutrophil levels in Japanese patients on a long-term CombivirR containing regimen. J.Clin.Virol. 33:188-193, 2005

Matsushita S., Yoshimura, K., Kimura T., Kamihira, A., Takano, M., Eto, K., Shirasaka, T., Mitsuya, H., Oka, S.: Spontan...
Publication

Sakaguchi N, Kimura T., Matsushita S, Fujimura S, Shibata J, Araki M, Sakamoto T, Minoda S, and Kuwahara K.Generation of high-affinity antibody against T cell- dependent antigen in ganp gene- transgenic mouse. J. Immunol. 174:4485-4494,2005.

Sakaguchi N, Kimura T., Matsushita S, Fujimura S, Shibata J, Araki M, Sakamoto T, Minoda S, and Kuwahara K.Generation of...
Publication

Matsushita S, Takahama S., Shibata J., Kimura T., Shiozaki K., Eda Y., Koito A., Murakami T, and Yoshimura K. Ex vivo neutralization of HIV-1 quasispecies by a broadly reactive humanized monoclonal antibody KD247. Human Antibodies. 14:80-88, 2005

Matsushita S, Takahama S., Shibata J., Kimura T., Shiozaki K., Eda Y., Koito A., Murakami T, and Yoshimura K. Ex vivo ne...
Domestic Conference

松下修三:Introductory comments on HIV residual diseases(イントロダクション:HAART で残存するウイルスとは?)第18回日本エイズ学会学術集会. 2004.12.9-11. 静岡.

松下修三:Introductory comments on HIV residual diseases(イントロダクション:HAART で残存するウイルスとは?)第18回日本エイズ学会学術集会. 2004.12.9-11. 静岡.
Domestic Conference

岩田隆一、柴田潤二、木村哲也、吉村和久、小糸厚、松下修三:自己由来のHIV に対して中和活性をもつ血清中和抗体の交差中和性の 研究.第18回日本エイズ学会学術集会. 2004.12.9-11. 静岡.

岩田隆一、柴田潤二、木村哲也、吉村和久、小糸厚、松下修三:自己由来のHIV に対して中和活性をもつ血清中和抗体の交差中和性の 研究.第18回日本エイズ学会学術集会. 2004.12.9-11. 静岡.
Domestic Conference

柴田潤二、木村哲也、岩田隆一、吉村和久、小糸厚、松下修三: gp 120 のC3領域変異による抗V3中和抗体に対する中和抵抗性の獲得自己由来のHIV に対して中和活性をもつ血清中和抗体の交差中和性の研究. 第18回日本エイズ学会学術集会. 2004.12.9-11. 静岡.

柴田潤二、木村哲也、岩田隆一、吉村和久、小糸厚、松下修三: gp 120 のC3領域変異による抗V3中和抗体に対する中和抵抗性の獲得自己由来のHIV に対して中和活性をもつ血清中和抗体の交差中和性の研究. 第18回日本エイズ学会学術集会. ...
Domestic Conference

濱本理恵子、祁内 梓、吉村和久、小糸 厚、松下修三:HIV感染患者におけるヘルパーT細胞活性に対する制御性T細胞の影響.第34回日本免疫学会総会・学術集会. 2004.12.1-3. 札幌.

濱本理恵子、祁内 梓、吉村和久、小糸 厚、松下修三:HIV感染患者におけるヘルパーT細胞活性に対する制御性T細胞の影響.第34回日本免疫学会総会・学術集会. 2004.12.1-3. 札幌.
Domestic Conference

祁内 梓、木村 哲也、吉村 和久、小糸 厚、松下 修三: HIV Tat-Nef融合タンパクを用いた細胞性・液性免疫の誘導. 第34回日本免疫学会総会・学術集会. 2004.12.1-3. 札幌. 

祁内 梓、木村 哲也、吉村 和久、小糸 厚、松下 修三: HIV Tat-Nef融合タンパクを用いた細胞性・液性免疫の誘導. 第34回日本免疫学会総会・学術集会. 2004.12.1-3. 札幌. 
Domestic Conference

小糸厚、柴田潤二、大杉剛生、松下修三、亀山祐一:小動物由来APOBEC3Gの抗HIV-1活性の解析. 第52回日本ウイルス学会学術集会.2004.11.21-23. 横浜

小糸厚、柴田潤二、大杉剛生、松下修三、亀山祐一:小動物由来APOBEC3Gの抗HIV-1活性の解析. 第52回日本ウイルス学会学術集会.2004.11.21-23. 横浜
International Conference

Matsushita,S.: International symposium of AIDS Research Institute in Yonsei University College of Medicine“HIV/AIDS”. 2004.10.15. Seoul, Korea.

Matsushita,S.: International symposium of AIDS Research Institute in Yonsei University College of Medicine“HIV/AIDS”. 20...
International Conference

Iwata, R., Shibata, J., Kimura, T., Yoshimura K., Koito, A., Matsushita, S.: Cross neutralizing activity of serum antibodies with neutralizing activity against autologous HIV. 5th AIDS seminar in Kumamoto 2004.9.9-10.Kumamoto.

Iwata, R., Shibata, J., Kimura, T., Yoshimura K., Koito, A., Matsushita, S.: Cross neutralizing activity of serum antibo...
International Conference

Shibata, J., Wang, F.X., Kimura, T., Iwata R., Yoshimura K., Koito, A., Matsushita, S.: Involvement of C3 mutation in neutralization sensitivity for anti-V3 antibodies. 5th AIDS seminar in Kumamoto 2004.9.9-10.Kumamoto.

Shibata, J., Wang, F.X., Kimura, T., Iwata R., Yoshimura K., Koito, A., Matsushita, S.: Involvement of C3 mutation in ne...
International Conference

Matsushita, S., Kimura, T., Shirai, N., Koito, A., Yoshimura, K. New approach for optimization of HAART; Evaluation of residual viral replication by monitoring proviral DNA level and T cell turnover rate. XV International AIDS Conference Bangkok, 2004.7.11-16, Bangkok, Thailand.

Matsushita, S., Kimura, T., Shirai, N., Koito, A., Yoshimura, K. New approach for optimization of HAART; Evaluation of r...
International Conference

Kenai, A., Kimura, T., Yoshimura K., Koito, A., Matsushita, S.: Efficient induction of both cellular and humoral immune responss by immuniztion with Tat-Nef fusion protein (tNEF) without adjuvants. XV International AIDS Conference Bangkok, 2004.7.11-16, Bangkok, Thailand.

Kenai, A., Kimura, T., Yoshimura K., Koito, A., Matsushita, S.: Efficient induction of both cellular and humoral immune ...
Publication

Tamiya S., Mardy S., Kavlick M.F., Yoshimura K, Mistuya H.  Amino acid insertions near Gag cleavage sites restore the otherwise compromised replication of human immunodeficiency virus type 1 variants resistant to protease inhibitors. J. Virol. 78:12030-12040, 2004.

Tamiya S., Mardy S., Kavlick M.F., Yoshimura K, Mistuya H.  Amino acid insertions near Gag cleavage sites restore the o...
International Conference

Matsushita S., Kimura T., Shirai N., Koito A., Yoshimura K.: Evaluation of residual viral replication for optimization of HAART. 1st International Workshop on HIV Persistence during Therapy. 12.10-12, 2003,Saint Martin, FWI.

Matsushita S., Kimura T., Shirai N., Koito A., Yoshimura K.: Evaluation of residual viral replication for optimization o...
Domestic Conference

祁内 梓、木村哲也、吉村和久、小糸 厚、松下修三: HIV-nef融合蛋白を用いた細胞性・液性免疫の誘導. 第17回日本エイズ学会学術集会・総会、11.27-29, 2003, 神戸

祁内 梓、木村哲也、吉村和久、小糸 厚、松下修三: HIV-nef融合蛋白を用いた細胞性・液性免疫の誘導. 第17回日本エイズ学会学術集会・総会、11.27-29, 2003, 神戸
Domestic Conference

木村哲也、吉村和久、祁内 梓、小糸 厚, 松下修三: HIVエンベロープC3変異による抗HIV中和抗体からの逃避. 第17回日本エイズ学会学術集会・総会、11.27-29, 2003, 神戸

木村哲也、吉村和久、祁内 梓、小糸 厚, 松下修三: HIVエンベロープC3変異による抗HIV中和抗体からの逃避. 第17回日本エイズ学会学術集会・総会、11.27-29, 2003, 神戸
Domestic Conference

吉村和久、木村哲也、松下修三:Proviral DNA (pDNA) and turn over levels in HIV-1-positive long-term non-progressors (LTNPs). 第17回日本イズ学会学術集会・総会、11.27-29, 2003, 神戸

吉村和久、木村哲也、松下修三:Proviral DNA (pDNA) and turn over levels in HIV-1-positive long-term non-progressors (LTNPs). 第17回日本イズ学会学...
International Conference

Yoshimura K, Kimura T, Matsushita S: Proviral DNA (pDNA) and turn over levels in HIV-1-positive long-term non-progressors (LTNPs). 2003 International Meeting of the Institute ofHuman Virology. 9.29-10.3 2003,Baltimore,U.S.A..

Yoshimura K, Kimura T, Matsushita S: Proviral DNA (pDNA) and turn over levels in HIV-1-positive long-term non-progressor...
International Conference

Matsushita S. Status of HIV/AIDS inJapan. International Symposium of the Foundation ofEast Asia Network on HIV. 9.26, 2003,Seoul,Korea.

Matsushita S. Status of HIV/AIDS inJapan. International Symposium of the Foundation ofEast Asia Network on HIV. 9.26, 20...
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