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Publication

Koito A, Shigekane H, Matsushita S. Ability of small animal cells to support post integration phase of human immunodeficiency virus type 1 replication. Virology, 305:181-191, 2003.

Koito A, Shigekane H, Matsushita S. Ability of small animal cells to support post integration phase of human immunodefic...
Publication

Koito A,Kameyama Y, Cheng-Mayer C, Matsushita S. Susceptibility of mink (Mustera vision)-derived cells to replication by human immunodeficiency virus type-1. J Virol, 77:5109-511, 2003

Koito A,Kameyama Y, Cheng-Mayer C, Matsushita S. Susceptibility of mink (Mustera vision)-derived cells to replication b...
Publication

Yoshimura K, Ido E., Akiyama H, Kimura T, Aoki M, Suzuki H., Mitsuya H, Hayami M, Matsushita S. The impact of highly active antiretroviral therapy by the oral route on the CD8 subset in monkeys infected chronically with SHIV89.6P. J Virol Methods. 112:121-128, 2003.

Yoshimura K, Ido E., Akiyama H, Kimura T, Aoki M, Suzuki H., Mitsuya H, Hayami M, Matsushita S. The impact of highly ac...
International Conference

Matsushita S.: Anti-HIV immunity of patients with long-term viral suppression by HAART. U.S.-Japan Cooperative Medical Science Program 15th Joint Meeting of the AIDS Panels, 3.5-7, 2003,Okinawa.

Matsushita S.: Anti-HIV immunity of patients with long-term viral suppression by HAART. U.S.-Japan Cooperative Medical S...
Domestic Conference

木村哲也, 吉村和久、小糸 厚、松下修三:Dual tropic virusに対する中和抗体活性とcoreceptor usage第16回日本エイズ学会学術集会.総会. 2002.11.28-11.30.名古屋.

木村哲也, 吉村和久、小糸 厚、松下修三:Dual tropic virusに対する中和抗体活性とcoreceptor usage第16回日本エイズ学会学術集会.総会. 2002.11.28-11.30.名古屋.
Domestic Conference

松下修三:HIV感染症治療の最適化を目的としたプロテアーゼ阻害剤の血中濃度測定. 第 16回日本エイズ学会学術集会.総会. 2002.11.28-11.30.名古屋.

松下修三:HIV感染症治療の最適化を目的としたプロテアーゼ阻害剤の血中濃度測定. 第 16回日本エイズ学会学術集会.総会. 2002.11.28-11.30.名古屋.
Domestic Conference

吉村和久、木村哲也、小糸 厚、松下修三:HIV感染症治療の最適化に関する研究p-DNAとT-cell turenoverの測定.第16回日本エイズ学会学術集会.総会. 2002.11.28-11.30.名古屋.

吉村和久、木村哲也、小糸 厚、松下修三:HIV感染症治療の最適化に関する研究p-DNAとT-cell turenoverの測定.第16回日本エイズ学会学術集会.総会. 2002.11.28-11.30.名古屋.
International Conference

Kimura T, Yoshimura K, Koito A, Matsushita S: Antibody-mediated neutralization against dual tropic viruses depends on coreceptor usages. XIV International AIDS Conference. 2002.7.7-12,Barcelona,Spain.

Kimura T, Yoshimura K, Koito A, Matsushita S: Antibody-mediated neutralization against dual tropic viruses depends on co...
International Conference

Yoshimura K, Wang FX, Kimura T, Koito A, Matsushita S: Detecting the residual replication level to potentiate HAART regimen for a salvage therapy. XIV International AIDS Conference.. 2002.7.7-12,Barcelona,Spain.

Yoshimura K, Wang FX, Kimura T, Koito A, Matsushita S: Detecting the residual replication level to potentiate HAART regi...
International Conference

Matsushita S, Kimura T, Wang FX, Kim J, Koito A, Yoshimura K: Reconstitution of autologous isolate neutralizing antibody under HAART and emergence of neutralization escape mutants in vivo. XIV International  AIDS Conference. 2002.7.7-12,Barcelona,Spain.

Matsushita S, Kimura T, Wang FX, Kim J, Koito A, Yoshimura K: Reconstitution of autologous isolate neutralizing antibody...
International Conference

Matsushita S, Wang FX, Kimura T, Nishihara K,Yoshimura K, Koito A: HIV quasispecies and neutralization escape in vivo. 14th Joint AIDS Panels Meeting,March 19-21, 2002,Seattlle,U.S.A.

Matsushita S, Wang FX, Kimura T, Nishihara K,Yoshimura K, Koito A: HIV quasispecies and neutralization escape in vivo. 1...
Publication

Gatanaga, H., Suzuki, Y., Tsang, H., Yoshimura, K., Kavlick, M.F., Nagashima, K., Gorelick, R.J., Mardy, S., Tang, C., Summers, M.F., Mitsuya, H.: Amino acid substitutions in gag protein at non-cleavage sited are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors. J. Biol. Chem. 277:5952-5961, 2002.

Gatanaga, H., Suzuki, Y., Tsang, H., Yoshimura, K., Kavlick, M.F., Nagashima, K., Gorelick, R.J., Mardy, S., Tang, C., S...
Publication

Matsushita, S. Kimura, T. Advance in treatment strategy and immune reconstruction against HIV-1 infection. Microbiol. Immunol., 46(4):231-239, 2002. [PDF]

Matsushita, S. Kimura, T. Advance in treatment strategy and immune reconstruction against HIV-1 infection. Microbiol. Im...
Publication

Wang FX, Kimura T, Nishihara K., Yoshimura K.,Koito A, Matsushit S. Emergence of autologous neutralization-resistant variants from pre existing quasispecies during viral-rebound of human immunodeficency virus type-1 infected patients under treatment of highly active anti retroviral therapy (HAART) . J Infect Dis, 185:608-617, 2002.

Wang FX, Kimura T, Nishihara K., Yoshimura K.,Koito A, Matsushit S. Emergence of autologous neutralization-resistant va...
Publication

Kimura T, Yoshimura K., Nishihara K., Maeda Y, Matsumi S,Koito A, Matsushita S. Reconstitution of spontaneous neutralizing antibody response against autologous HIV-1 in chronically infected patients during highly active antiretroviral therapy. J. Infect. Dis., 185:53-60,  2002.

Kimura T, Yoshimura K., Nishihara K., Maeda Y, Matsumi S,Koito A, Matsushita S. Reconstitution of spontaneous neutralizi...
Publication

Yoshimura K, Kato R , Kavlick MF, Nguyen A, Maroun V, Maeda K., Hussain K., Ghosh A., Erickson J, Mitsuya H. A Potent Protease Inhibitor (PI) UIC-94003 Interacting with Main Chains of HIV Protease Active Site Amino Acids and the Development of a Novel Mutation A28S in the Protease of UIC-94003-Resistant HIV. J Virol, 76:1349-1357, 2002.

Yoshimura K, Kato R , Kavlick MF, Nguyen A, Maroun V, Maeda K., Hussain K., Ghosh A., Erickson J, Mitsuya H. A Potent Pr...
Domestic Conference

松下修三:抗HIV薬の選び方.ロピナビル/rという選択.第15回日本エイズ学会ランチョンセミナー.2001.12.1.東京.

松下修三:抗HIV薬の選び方.ロピナビル/rという選択.第15回日本エイズ学会ランチョンセミナー.2001.12.1.東京.
Domestic Conference

吉村和久、木村哲也、西原久美子、松下修三: residual replicationの新しい指標?高感度プロウイルスDNA(pDNA)の定量と細胞ターンオーバーの測定.第15回日本エイズ学会学術集会総会. 2001.11.29-12.1.東京.

吉村和久、木村哲也、西原久美子、松下修三: residual replicationの新しい指標?高感度プロウイルスDNA(pDNA)の定量と細胞ターンオーバーの測定.第15回日本エイズ学会学術集会総会. 2001.11.29-12.1.東...
Domestic Conference

小糸 厚, 重兼弘法、松下修三:異種細胞HIV-1アッセンブリー阻害の解析.第15回日本エイズ学会学術集会.総会. 2001.11.29-12.1.東京.

小糸 厚, 重兼弘法、松下修三:異種細胞HIV-1アッセンブリー阻害の解析.第15回日本エイズ学会学術集会.総会. 2001.11.29-12.1.東京.
Domestic Conference

王 鳳香、木村哲也、吉村和久、小糸 厚、松下修三: Emergence of autologous neutralization resistant variants from pre-existing quasispecies during viral-rebound of HIV-1 infected patietns undergoing HAART. 第15回日本エイズ学会学術集会総会. 2001.11.29-12.1. 東京.

王 鳳香、木村哲也、吉村和久、小糸 厚、松下修三: Emergence of autologous neutralization resistant variants from pre-existing quasispecies durin...
Domestic Conference

松下修三:overview「免疫応答によるHIV感染・増殖の制御」.第49回日本ウイルス学会学術集会総会. 2001.11.18.大阪市.

松下修三:overview「免疫応答によるHIV感染・増殖の制御」.第49回日本ウイルス学会学術集会総会. 2001.11.18.大阪市.
International Conference

Wang FX, Kimura T, Nishihara K, Yoshimura K, Koito A, Matsushita S:Emergence of autologous neutralizaton resistant variants from Pre-existing quasispecies during viral-rebound of HIV-1 infected patients undergoing HAART. 2nd AIDS Seminor inKumamoto. 9.20-21, 2001.

Wang FX, Kimura T, Nishihara K, Yoshimura K, Koito A, Matsushita S:Emergence of autologous neutralizaton resistant varia...
International Conference

Koito A., Shigekane H., Matsushita S: Assembly defects of HIV-1 gag in murine cells. 2nd AIDS Seminor in Kumamoto.  9.20-21 2001.

Koito A., Shigekane H., Matsushita S: Assembly defects of HIV-1 gag in murine cells. 2nd AIDS Seminor in Kumamoto.  9.20...
International Conference

Wang FX, Kimura T, Nishihara K, Yoshimura K, Koito A, Matsushita S:Emergence of autologous neutralizaton resistant variants from Pre-existing quasispecies during viral-rebound of HIV-1 infected patients under treatment of HAART. 2001 International Meeting of the Institute of Human Virology. 9.9 -13, 2001.Baltimore, U.S.A

Wang FX, Kimura T, Nishihara K, Yoshimura K, Koito A, Matsushita S:Emergence of autologous neutralizaton resistant varia...
Domestic Conference

松下修三:感染症研究の新戦略.第25回阿蘇シンポジウム.2001.8.25. 熊本県阿蘇町

松下修三:感染症研究の新戦略.第25回阿蘇シンポジウム.2001.8.25. 熊本県阿蘇町
Publication

Maeda, K., Yoshimura, K., Shibayama, S., Habashita, H., Tada, H., Sagawa, K., Miyakawa, T., Aoki, M., Fukushima, D., and Mitsuya, H. Novel Low Molecular Weight Spirodiketopiperazine Derivatives Potently Inhibit R5 HIV-1 Infection through Their Antagonistic Effects on CCR5. J. Biol. Chem. 276:35194-35200, 2001.

Maeda, K., Yoshimura, K., Shibayama, S., Habashita, H., Tada, H., Sagawa, K., Miyakawa, T., Aoki, M., Fukushima, D., and...
Publication

Ikegawa M, Matsumoto K, Herrmann S, Iwamoto A, Nakamura T, Matsushita S, Nakamura T, Honjo T, Tashiro K: Elevated plasma SDF-1 protein level in the progression of HIV-1 infection/AIDS. AIDS Res Hum Retrov. 17(7):587-595, 2001

Ikegawa M, Matsumoto K, Herrmann S, Iwamoto A, Nakamura T, Matsushita S, Nakamura T, Honjo T, Tashiro K: Elevated plasma...
Publication

Sei, S., Yang, Q. E., O’Neill, D., Yoshimura, K., Nagashima, K., and Mitsuya, H. Identification of a key target sequence to block human immunodeficiency virus type 1 replication within the gag-pol transframe domain. J. Virol. 74:4621-33, 2000.

Sei, S., Yang, Q. E., O'Neill, D., Yoshimura, K., Nagashima, K., and Mitsuya, H. Identification of a key target sequence...
Publication

Falloon, J., Piscitelli, S., Vogel, S., Sadler, B., Mitsuya, H., Kavlick, M. F., Yoshimura, K., Rogers, M., LaFon, S., Manion, D. J., Lane, H. C., and Masur, H. Combination therapy with amprenavir, abacavir, and efavirenz in human immunodeficiency virus (HIV)-infected patients failing a protease- inhibitor regimen: pharmacokinetic drug interactions and antiviral activity. Clin. Infect. Dis. 30:313-308, 2000.

Falloon, J., Piscitelli, S., Vogel, S., Sadler, B., Mitsuya, H., Kavlick, M. F., Yoshimura, K., Rogers, M., LaFon, S., M...
Publication

Ohrui, H., Kohgo, S., Kitano, K., Sakata, S., Kodama, E., Yoshimura, K., Matsuoka, M., Shigeta, S., and Mitsuya, H. Syntheses of 4′-C-Ethynyl-beta-D-arabino- and 4′-C-Ethynyl-2’deoxy- beta-D-ribo-pentofuranosylpyrimidines and -purines and Evaluation of Their Anti-HIV Activity. J. Med. Chem. 43:4516-4525, 2000.

Ohrui, H., Kohgo, S., Kitano, K., Sakata, S., Kodama, E., Yoshimura, K., Matsuoka, M., Shigeta, S., and Mitsuya, H. Synt...
Publication

Murakami T, Nakajima N, Nakamura T, Hara A., Uyama E., Mita S, Matsushita S, Uchino M. Parkinsonian symptoms as an initial manifestation in a Japanese patient with acquired immunodeficiency syndrome and toxoplasma infection. Internal Medicine 39, 1111-1114, 2000.

Murakami T, Nakajima N, Nakamura T, Hara A., Uyama E., Mita S, Matsushita S, Uchino M. Parkinsonian symptoms as an initi...
Publication

Tugarinov V, Zvi A, Levy R, Hayek Y, Matsushita S, Anglister J. NMR structure of an anti gp-120 antibody complex with a V3-peptide reveals a surface important for co-receptro binding. Structure 8, 385-395. 2000.

Tugarinov V, Zvi A, Levy R, Hayek Y, Matsushita S, Anglister J. NMR structure of an anti gp-120 antibody complex with a ...
Publication

Matsushita S. Current status and future issues in the treatment of HIV infection. Int. J. Hematol. 72(1):20-27, 2000

Matsushita S. Current status and future issues in the treatment of HIV infection. Int. J. Hematol. 72(1):20-27, 2000
Publication

Maeda Y, Foda M, Matsushita S, Harada S. Involvement of both V2 and V3 region of CCR5-tropic human immunodeficiency virus type-1 envelope for reduced sensitivity to macrophage inflammatory protein α J Virol 74(4), 1787-1793, 2000

Maeda Y, Foda M, Matsushita S, Harada S. Involvement of both V2 and V3 region of CCR5-tropic human immunodeficiency vi...
Publication

Yoshimura K, Kato R, Yusa K, Kavlick MF, Maroun V, Nguyen A, Mimoto T, Ueno T, Shintani M, Falloon J, Masur H, Hayashi H, Erickson J, Mitsuya H. JE-2147: a dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1. Proc Natl Acad Sci USA. 96:8675-80., 1999.

Yoshimura K, Kato R, Yusa K, Kavlick MF, Maroun V, Nguyen A, Mimoto T, Ueno T, Shintani M, Falloon J, Masur H, Hayashi H...
Publication

Yoshimura K,Feldman R, Kodama E, Kavlick MF, Qiu YL, Zemlicka J, Mitsuya H. In vitro induction of human immunodeficiency virus type 1 variants resistant to phosphoralaninate prodrugs of Z-methylenecyclopropane nucleoside analogues. Antimicrob Agents Chemother. 43:2479-83, 1999.

Yoshimura K,Feldman R, Kodama E, Kavlick MF, Qiu YL, Zemlicka J, Mitsuya H. In vitro induction of human immunodeficiency...
Publication

Matsumi S, Maeda Y, Kimura T, Matsushita S. Effect of the Th1 and Th2 stimulatory cytokines, IL-12 and IL-4, on HIV-1 specific CTL activity. 12th World AIDS Conference, Appendix 5: 45-50, 1998.

Matsumi S, Maeda Y, Kimura T, Matsushita S. Effect of the Th1 and Th2 stimulatory cytokines, IL-12 and IL-4, on HIV-1 sp...
Publication

Wang J, Harada K., Matsushita S, Matsumi S, Zhang Y, Shioda T, Nagai Y, Matsushima K. IL-4 and a glucocorticoid up-regulate CXCR4 expression on human CD4+ T lymphocytes and enhance HIV-1 replication. J. Leukocyte Biology., 64:642-649,1998.

Wang J, Harada K., Matsushita S, Matsumi S, Zhang Y, Shioda T, Nagai Y, Matsushima K. IL-4 and a glucocorticoid up-regul...
Publication

Shoji S, Kazuchika K, Ogata A, Yamataka K., Mukai K., Uda A., Harano S, Matsushita S, Misumi S. An allisteric drug, o’o’-bismyristoyl thiamine disulfide, suppresses HIV-1 replication through prevention of nuclear translocation of both HIV-1 tat and NF-ΚB. Biochem. Biophys. Res. Commun., 249, 745-753, 1998.

Shoji S, Kazuchika K, Ogata A, Yamataka K., Mukai K., Uda A., Harano S, Matsushita S, Misumi S. An allisteric drug, o'o'...
Publication

Hakata Y, Umemoto T., Matsushita S, Shida H. Involvement of human CRM1 (Exportin 1) in the export and multimerization of the Rex protein of the human T-cell leukemia virus type 1. J. Virol. 72: 6602-6607, 1998.

Hakata Y, Umemoto T., Matsushita S, Shida H. Involvement of human CRM1 (Exportin 1) in the export and multimerization of...
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