Archive for 2015

  • 松下修三、中本泰充、池田篤史、Pozniak, A、Arribas, J、Gupta, S、Post, F、Fordyce, M. 軽度から中等度の腎機能障害があるHIV 1 感染症患者に E/C/F/TAF を投与した第 III 相臨床試験におけるアジア人での有効性及び安全性の評価.    第29回日本エイズ学会学術集会・総会. 2015年11月30日-12月1日,東京.

  • Muntasir, A., Kuwata, T., Ramirez, K., Maruta, Y., Tanaka, K., Shimura, K., Oishi, S., Fujii, N., Matsuoka, M., Matsushita, S.   Effect of gp41 mutations on the sensitivity to neutralizing antibodies against HIV.  第29回日本エイズ学会学術集会・総会. 2015年11月30日-12月1日,東京.

  • 平田 泉、桑田岳夫、丸田泰広、田中和樹、Muntasir, A.、松下修三 ファージ・ライブラリーを用いた抗 V3単クローン抗体のエピトープ解析. 第29回日本エイズ学会学術集会・総会. 2015年11月30日-12月1日,東京.

  • Kuwata, T., Shimizu,  M., Matsushita, S.   Impact of gp41 mutations on resistance to B404, a broad neutralizing antibody reactive against a conformational epitope of SIV gp120. 第63回日本ウイルス学会学術集会. 2015年11月22日-24日,福岡市.

  • Tanaka, K. Kuwata T., Maruta, Y., Muntasir, A., Kawanami, Y.,Matsushita, S.  Enhanced neutralization by small antibody fragments targeting CD4i (CD4-induced) epitope on HIV-1 envelope glycoprotein. 第63回日本ウイルス学会学術集会. 2015年11月22日-24日,福岡市.

  • 2015/10/20 新しい論文発表の情報はこちらから

  • Ramirez, K., Kuwata, T., Maruta, Y., Tanaka, K., Alam, M., Yoshimura, K., Matsushita, S. Complementary and synergistic activities of anti-V3, CD4bs and CD4i antibodies derived from a single individual can cover a wide range of HIV-1 strains. Virology, 475, 187-203, 2015. doi:10.1016/j.virol.2014.11.011

  • Matsushita, S., Yoshimura, K., Ramirez, k., Pisupati, J., Murakami, T., the KD-1002 Study Group. Passive transfer of neutralizing mAb KD-247 reduces plasma viral load in patients chronically infected with HIV-1. AIDS, 29(4), 453-462, 2015.
    doi: 10.1097/QAD.0000000000000570

  • 2015/10/20 新しい国内学会の情報はこちらから

  • 2015/10/19 新しいメンバー情報はこちらから

  • 2015/10/19  新しい国際学会の情報はこちらから

  • Stanoeva, K., Fukuda, A., Kawanami, Y, Kuwata, T., Satou, Y., Matsushita, S.: Levels of integrated proviral HIV-1 DNA load in Japanese patients on long-term ART. 16th Kumamoto AIDS Seminar. October 7-9, 2015. Kumamoto.

  • Maruta, Y., Kuwata, T., Tanaka, K., Ramirez, K., Alam, M., Egami, Y., Suwa, Y., Morioka, H., Matsushita, S.: Post-attachment neutralization by single-chain variable fragments targeting the V3 loop of HIV-1 envelope. 16th Kumamoto AIDS Seminar. October 7-9, 2015. Kumamoto.

  • Alam, M., Kuwata, T., Maruta, Y., Ramirez K., Tanaka, K., Shimura, K., Oishi, S., Fujii, N., Matsuoka, M., Matsushita, S.: HIV-1 gp41 mutations against fusion inhibitor C34 showed enhanced sensitivity to neutralizing antibodies. 16th Kumamoto AIDS Seminar. October 7-9, 2015. Kumamoto.

  • Tanaka, K., Kuwata, T., Maruta, Y., Ramirez K., Alam, M., Kawanami, Y., Matsushita S.: Enhanced neutralization of HIV-1 primary isolates by the small antibody fragments targeting CD4-induced (CD4i) epitope. 16th Kumamoto AIDS Seminar. October 7-9, 2015. Kumamoto.

  • Alves, G., Kuwata T., Tanaka Y., Ariumi, Y., Maruta, Y., Tanaka, K., Alam, M., Stanoeva, K., Hirata, I., Matsushita, S.: Constitutive expression of anti-HIV-1 scFv intrabodies transduced by an HIV-1-based Lentivirus vector. 16th Kumamoto AIDS Seminar. October 7-9, 2015. Kumamoto.

  • Hirata, I., Kuwata, T., Maruta, Y., Tanaka, K., Alam, M., Matsushita, S.: Epitope analysis of anti-V3 monoclonal antibodies using phage display library. 16th Kumamoto AIDS Seminar. October 7-9, 2015. Kumamoto.

  • Kuwata, T., Shimizu, M., Matsushita, S. Impact of gp41 mutations for escape from a broad neutralizing antibody against SIV. 16th Kumamoto AIDS Seminar. October 7-9, 2015. Kumamoto.

  • IAS 2015  Vancouver,Canada(2015/7/19-22)にて、博士課程3年の田中和樹さんが「IAS  Towards an HIV Cure Scholarship Programme」を獲得しました。

     詳しい情報はこちらから

  • Tanaka, K., Kuwata, T., Maruta, Y., Ramirez, K., Alam, M., Egami, Ikumi Y., Enomoto, I., Kawanami, Y., Matsushita. S. Potent and broad neutralizing activity of small antibody fragments targeting CD4i (CD4-induced) epitope. The 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015) the Vancouver 19-22 July 2015. Vancouver, Canada.

  • 桑田岳夫、田中和樹、丸田泰広、松下修三. Neutralization of HIV-1 by single chain antibody fragments (scFv) against gp120. 白馬シンポジウム in 米子. 2015年6 月19 日-20 日, 米子市.

  • 田中和樹、桑田岳夫、丸田泰広、松下修三.  Potent and broad neutralizing activity of small antibody fragments targeting CD4i (CD4-induced) epitope. 白馬シンポジウム in 米子. 2015年6 月19 日-20 日(土).米子市.

  • Muntasir, A., Kuwata, T., Ramirez, K., Maruta, Y., Tanaka K., Shimura, K., Oishi, S., Fujii, N., Matsuoka, M., Matsushita, S. Enhanced Neutralization of HIV-1 with Fusion Inhibitor Resistant Mutations. The annual Conference on Retroviruses and Opportunistic Infections (CROI 2015). February 23-26, 2015. Seattle, Washington, USA

  • Matsushita, S., Ramirez, K.P., Maruta, Y., Tanaka, K., Muntasir, A., Kuwata, T., Pisupait, J., Murakami, T., Yoshimura, K. Therapeutic application of neutralizing antibodies based on the recent data on complementary and synergistic activities against a wide range of HIV-1 strains. the 17th International Conference on Emerging Infectious Diseases (EID) Emerging Infectious Diseases Meeting Jan. 26-27, 2015. Taipei, Taiwan

  • Kirby, K.A., Ong Y.T., Hachiya, A., Laughlin, T.G., Chiang, L.A., Pan, Y., Moran, J.L., Marchand, B., Singh, K., Gallazzi, F., Quinn, T.P., Yoshimura, K., Murakami, T., Matsushita, S., Sarafianos, S.G.. Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247. The FASEB Journal, 29(1), 70-80, 2015.

  • Maruta, Y ., Kuwata, T., Tanaka, K ., Nakahara, Y ., Ramirez, K., Muntasir, A., Egami, Y., Hirata, I., Suwa, Y ., Morioka, H., Matsushita, S. Post-attachment Neutralization by Single-chain Variable Fragment (scFv) from an Anti-V3 Monoclonal Antibody with Cross-reactivity. Korea-Japan Joint Seminar on HIV/AIDS. January 10, 2015. Kumamoto.