Archive for 2014

  • Ramirez, K.P., Kuwata, T., Maruta, Y, Tanaka K., Muntasir, A., Yoshimura, K., Matsushita, S. Complementary effect of anti-V3, CD4bs and CD4i antibodies accounts for cross-neutralizing and non-neutralizing activities against HIV-1. 第28回日本エイズ学会学術集会・総会. 2014年12月3日-5日, 大阪.

  • 江上由華、丸田泰広、田中和樹、Muntasir A., Ramirez K., 桑田岳夫、松下修三.  V3エピトープへの交叉反応性をもつ中和抗体の遺伝子組み換えによる小型化の試み.  第28回日本エイズ学会学術集会・総会. 2014年12月3日-5日, 大阪.

  • 桑田岳夫、松下修三. 強力な抗SIV中和抗体B404からの逃避メカニズムの解析. 第28回日本エイズ学会学術集会・総会. 2014年12月3日-5日, 大阪.

  • Kuwata, T., Yoshimura, K., Wu, F., Ourmanov, I., Hirsch, V.M., Yokoyama, M., Sato H., and Matsushita, S.  Mutations in gp41 is Critical to Escape from B404, a Broad Neutralizing Antibody Against SIV, Which Recognizes a V3/V4 Conformational Epitope. 32nd Annual Symposium on Nonhuman Primate Models for AIDS. November 11 – 14, 2014. Portland, Oregon, USA.

  • Maruta, Y., Kuwata, T., Tanaka K., Nakahara,Y., Ramirez, K., Alam, M., Egami, Y., Hirata I., Suwa, Y., Morioka, H., Matsushita, S. Mechanism of post-attachment neutralization of single-chain variable fragment (scFv) from anti-V3 monoclonal antibody against HIV-1.  HIV R4P 2014 .  October 28-31,2014. Cape Town, South Africa. 

  • Yoshimura, K., Harada, S., Boonchawalit, S., Kawanami, Y., and Matsushita, S. Impact of maraviroc-resistant and low-CCR5- adapted mutations induced by in vitro passage on sensitivity to anti-envelope neutralizing antibodies. Journal of General Virology, 95, 1816-1826, 2014.

  • Matsushita, S., Ramirez, K.P., Maruta, Y., Tanaka, K., Muntasir, A., Kuwata, T., Pisupait, J., Murakami, T., Yoshimura, K. Therapeutic application of neutralizing antibodies based on the recent data on complementary and synergistic activities against a wide range of HIV-1 strains. 15th Kumamoto AIDS Seminar. October 1-3, 2014. Kumamoto.

  • Kuwata, T., Enomoto, I., Baba, M., Matsushita, S. Acquisition of resistance to the CCR5 antagonist cenicriviroc renders HIV-1 sensitive to neutralizing antibodies. 15th Kumamoto AIDS Seminar. October 1-3, 2014. Kumamoto.

  • Ramirez, K.P., Kuwata, T., Maruta, Y, Tanaka K., Muntasir, A., Yoshimura, K., Matsushita, S. Evaluation of complementarity and synergy of conventional anti-HIV-1 antibodies derived from a single individual, 15th Kumamoto AIDS Seminar. October 1-3, 2014. Kumamoto.

  • Muntasir, A., Kuwata, T., Ramirez, K., Enomoto, I., Maruta, Y., Tanaka K., Rahman K., Nakahara,Y., Egami, Y., Kawanami, Y., Murayama, H., Shimura, K., Matsuoka, M., Matsushita, S. Mutations in gp41 that confer resistance to fusion inhibitors enhance the neutralization sensitivity to antibodies against both gp41 and gp120. 15th Kumamoto AIDS Seminar. October 1-3, 2014. Kumamoto.

  • Maruta, Y., Kuwata, T., Tanaka K., Nakahara,Y., Ramirez, K., Alam, M., Egami, Y., Hirata I., Suwa, Y., Morioka, H., Matsushita, S. Mechanism of post-attachment neutralization of single-chain variable fragment (scFv) from anti-V3 monoclonal antibody against HIV-1. 15th Kumamoto AIDS Seminar. October 1-3, 2014. Kumamoto.

  • Tanaka K., Kuwata, T., Maruta, Y., Ramirez, K., Muntasir, A., Egami, Y., Enomoto, I., Kawanami, Y., Matsushita, S. Construction of neutralizing antibody fragment against V3 with a broad cross-reactivity. 15th Kumamoto AIDS Seminar. October 1-3, 2014. Kumamoto.

  • Boonchawalit, S., Harasda, S., Matsushita, S., Yoshimura, K.: Impact of Maraviroc (MCV)-resistant mutations in C1 and C4 regions of gp120 on sensitivity to antibody-mediated neutralization. 20th International AIDS Conference. Melbourne, Australia. July 20-25,2014.

  • 桑田岳夫:SIVサル・モデルを用いた中和抗体の解析. 第17回 日本レトロウイルス研究会 夏期セミナー.2014 7.3-5(7/3発表)静岡県熱海市.

  • 桑田岳夫、馬場昌範、松下修三:CCR5阻害薬Cenicrivirocへの耐性と中和抗体への抵抗性は両立しない. 白馬シンポジウムin熊本. 2014.6.13-14. 熊本市.

  • 桑田岳夫、馬場昌範、松下修三:HIV-1 のCCR5 阻害薬への耐性と中和抗体への抵抗性は両立しない第24回抗ウイルス療法研究会総会. 2014.5.7-9.(5/7発表)  山梨県富士吉田市.